When chest pain is not what it seems: time for right diagnosis and right treatment-a case report

Eur Heart J Case Rep. 2025 Sep 3;9(9):ytaf410. doi: 10.1093/ehjcr/ytaf410. eCollection 2025 Sep.ABSTRACTBACKGROUND: Chest pain is a common reason for emergency department (ED) visits, yet not all cases are attributable to coronary artery disease (CAD). The 2024 European Society of Cardiology (ESC) g

Exosomal LncRNA MALAT1 Derived from Hepatocytes in Nonalcoholic Fatty Liver Disease Regulates the miR-579-3p/Keap1/Nrf2 Pathway to Exacerbate Obstructive Sleep Apnea Syndrome

Mol Biotechnol. 2025 Sep 4. doi: 10.1007/s12033-025-01499-1. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVE: Obstructive sleep apnea syndrome (OSAS) is a common sleep breathing disorder, and nonalcoholic fatty liver disease (NAFLD) may affect OSAS. This study aimed to explore the influence o

Rituximab treatment for connective tissue diseases associated-pulmonary hypertension: a systematic literature review

Expert Rev Respir Med. 2025 Sep 4. doi: 10.1080/17476348.2025.2557634. Online ahead of print.ABSTRACTINTRODUCTION: To evaluate the efficacy and safety of Rituximab (RTX) in the treatment of pulmonary hypertension (PH) in patients with connective tissue diseases (CTDs).METHODS: A systematic review of

How to treat arterial hypertension effectively in elderly subjects?

Pol Arch Intern Med. 2025 Sep 3:17109. doi: 10.20452/pamw.17109. Online ahead of print.ABSTRACTHypertension is the most common cardiovascular risk factor in older adults, significantly contributing to morbidity and mortality. Its prevalence rises with age and is strongly associated with vascular agi

Supine hypertension and cardiovascular disease: controversies and advances

Future Cardiol. 2025 Sep 4:1-15. doi: 10.1080/14796678.2025.2550112. Online ahead of print.ABSTRACTElevated blood pressure is one of the most important risk factors for cardiovascular disease (CVD). Despite blood pressure being historically measured in the supine position prior to the 20th century,

Current status of the use of validated home blood pressure monitoring devices among Korean patients with hypertension

Hypertens Res. 2025 Sep 3. doi: 10.1038/s41440-025-02364-z. Online ahead of print.ABSTRACTThe implementation of Home Blood Pressure Monitoring (HBPM) has improved the diagnosis and treatment of hypertension. Current clinical guidelines advocate the use of validated HBPM devices. However, few studies

Benefit-harm trade-offs of intensive blood pressure control versus standard blood pressure control on cardiovascular and renal outcomes: an individual participant data analysis of randomised controlled trials

Lancet. 2025 Aug 28:S0140-6736(25)01391-1. doi: 10.1016/S0140-6736(25)01391-1. Online ahead of print.ABSTRACTBACKGROUND: Although intensive blood pressure control is recommended by major guidelines, its overall benefit-harm balance remains uncertain. In particular, it is unclear how net clinical ben

Lambl's Excrescences and Cardiac Papillary Fibroelastoma, an Unusual Cause of Embolic Strokes: Extended Data From a Single Center Case Series

Cureus. 2025 Jul 31;17(7):e89162. doi: 10.7759/cureus.89162. eCollection 2025 Jul.ABSTRACTBackground Lambl's excrescences (LE) and cardiac papillary fibroelastomas (CPF) are valvular structures that have been associated with cryptogenic strokes, potentially acting as embolic sources or sites of thro

Pharmacist-Led Digital Health Interventions to Improve Treatment Outcomes in Patients with Hypertension - A Systematic Review

J Multidiscip Healthc. 2025 Aug 27;18:5275-5287. doi: 10.2147/JMDH.S530575. eCollection 2025.ABSTRACTWith the advancement of digital technologies, pharmacist-led digital health interventions (DHI) have emerged as a promising strategy to improve hypertension management. This systematic review evaluat

Time to Acute Treatment in Intracerebral Hemorrhage Lags Significantly Behind Ischemic Stroke: A Multicenter, Observational Retrospective Study

Stroke. 2025 Sep 3. doi: 10.1161/STROKEAHA.125.051422. Online ahead of print.ABSTRACTBACKGROUND: Time-to-treatment goals for acute ischemic stroke (AIS) have substantially improved outcomes, yet similar metrics have not been studied in patients with intracerebral hemorrhage (ICH), where mortality ra

Validation status of digital blood pressure monitors in Peru: a comprehensive assessment with a validation-process algorithm proposal

Blood Press Monit. 2025 Aug 12. doi: 10.1097/MBP.0000000000000769. Online ahead of print.ABSTRACTBACKGROUND: In Latin America and the Caribbean (LAC), hypertension is the leading cause of death and disability. Accurate diagnosis requires validated blood pressure measurement devices (BPMD). This stud

Approach to Diagnosis and Management of Pediatric Hypertension in an Outpatient Setting

Indian J Nephrol. 2025 Jul-Aug;35(4):460-469. doi: 10.25259/IJN_385_2024. Epub 2025 May 21.ABSTRACTPediatric hypertension (HTN) is a public health concern with significant possible long-term adverse outcomes. This review is a comprehensive guide for pediatricians, nephrologists, and trainees, focusi

Central Adiposity and Anthropometric Indices as Gender-Specific Predictors of Systolic Blood Pressure in Young Adults

Cureus. 2025 Jul 29;17(7):e88961. doi: 10.7759/cureus.88961. eCollection 2025 Jul.ABSTRACTBackground Hypertension is a rising concern among young adults, driven by sedentary lifestyles, academic stress, and poor dietary habits. Medical students, despite being a theoretically low-risk group, exhibit

Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: Technical challenges and controversies

JHLT Open. 2025 Jul 30;10:100357. doi: 10.1016/j.jhlto.2025.100357. eCollection 2025 Nov.ABSTRACTChronic thromboembolic pulmonary hypertension requires referral to an expert center for final diagnosis and assessment of treatment possibilities by a multidisciplinary team. Pulmonary endarterectomy is

Statistical Analysis Plan for a Randomized Controlled Trial of Intensive Blood Pressure Control on Cardiovascular risk Reduction in Patients with Atrial Fibrillation

Cerebrovasc Dis. 2025 Sep 2:1-12. doi: 10.1159/000548288. Online ahead of print.ABSTRACTINTRODUCTION: Elevated blood pressure (BP) is a key modifiable risk factor for cardiovascular (CV) complications in patients with atrial fibrillation (AF). While current guidelines recommend modest BP targets, th

Orthostatic hypotension after kidney transplantation in a patient with diabetic kidney disease: an underrecognized and therapeutic challenge

CEN Case Rep. 2025 Sep 2. doi: 10.1007/s13730-025-01030-0. Online ahead of print.ABSTRACTOrthostatic hypotension (OH) is characterized by an excessive drop in blood pressure upon standing, leading to impaired quality of life, increased fall risk, and potential cardiovascular complications. It is fre

Efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer: a FRESCO-2 subgroup analysis of patients enrolled in Japan

Int J Clin Oncol. 2025 Sep 1. doi: 10.1007/s10147-025-02852-9. Online ahead of print.ABSTRACTBACKGROUND: In the phase 3 FRESCO-2 study, fruquintinib plus best supportive care (BSC) significantly improved overall survival (OS) versus placebo plus BSC in patients with refractory metastatic colorectal

Corticotherapy versus adrenocorticotropic hormone for treating West syndrome: a systematic review and meta-analysis

Arq Neuropsiquiatr. 2025 Aug;83(8):1-8. doi: 10.1055/s-0045-1811173. Epub 2025 Aug 31.ABSTRACTAlthough it is known that the most commonly used therapies for West syndrome (WS) are intramuscular adrenocorticotropic hormone (ACTH) and oral prednisolone, there is still controversy in the literature reg

Hypertensive retinopathy in Dutch emergency departments: a multicenter retrospective cohort analysis

Intern Emerg Med. 2025 Aug 30. doi: 10.1007/s11739-025-04105-z. Online ahead of print.ABSTRACTSuspected hypertensive emergencies account for approximately one in every 200 emergency department (ED) visits in the Netherlands. One manifestation of hypertensive-mediated organ damage (HMOD) is hypertens

Coconut Left Atrium: Causes and Management

Echocardiography. 2025 Sep;42(9):e70282. doi: 10.1111/echo.70282.ABSTRACTBACKGROUND: Cardiac calcification has multiple etiologies, including previous myocardial infarction, sepsis, and myocarditis. An imbalance between plasma calcium and phosphorus levels can also lead to cardiac calcification. Pat

Aligning HIV treatment and hypertension clinic visits and dispensing as a first step towards service delivery integration in South Africa

J Int AIDS Soc. 2025 Jul;28 Suppl 3(Suppl 3):e26444. doi: 10.1002/jia2.26444.ABSTRACTINTRODUCTION: Global and national guidelines recommend the integration of care for HIV and other chronic conditions to improve individual and public health outcomes. South Africa's differentiated service delivery (D

Cardiovascular toxicity in testicular germ cell tumor survivors

Front Oncol. 2025 Aug 13;15:1654063. doi: 10.3389/fonc.2025.1654063. eCollection 2025.ABSTRACTINTRODUCTION: Testicular germ cell tumors (TGCT) are highly curable malignancies, with excellent survival rates largely attributable to advances in cancer treatment. Consequently, there is a growing populat

Management of intracranial hypertension with and without invasive intracranial pressure monitoring

World J Crit Care Med. 2025 Sep 9;14(3):105645. doi: 10.5492/wjccm.v14.i3.105645. eCollection 2025 Sep 9.ABSTRACTManagement of intracranial hypertension (IH) has improved in the last decades driven by advancements in monitoring technologies and a deeper understanding of its pathophysiology. Although

Update of the Korean Clinical Practice Guidelines for Stroke: Blood Pressure Management

J Clin Neurol. 2025 Sep;21(5):370-383. doi: 10.3988/jcn.2025.0177.ABSTRACTHypertension is a major risk factor for stroke, and appropriate management of blood pressure (BP) is crucial for both prevention and treatment. Since the 2009 publication of the Clinical Practice Guideline (CPG) by the Korean