Drug Discov Today. 2025 Sep 2:104464. doi: 10.1016/j.drudis.2025.104464. Online ahead of print.
ABSTRACT
Liquid-liquid phase separation (LLPS), a phenomenon characterized by a membrane-free structure formed by weak multivalent interactions of intracellular biological macromolecules, has attracted wide attention in the study of chronic liver diseases in recent years. LLPS has multiple roles in the occurrence and development of chronic liver disease, including regulating virus replication, affecting lipid metabolism, regulating immune response, and participating in the regulation of gene expression. This article reviews the specific mechanism of LLPS in chronic liver disease, and discusses its potential application in drug development, immunotherapy, and gene therapy, providing new ideas for the treatment of chronic liver disease.
PMID:40907600 | DOI:10.1016/j.drudis.2025.104464