Impact of chronic consumption of probiotics, oats, and apples on expression of genes related to bile acids, lipid, gut peptides, and inflammation in peripheral monocular cells - findings from the CABALA study

Eur J Nutr. 2025 May 10;64(4):176. doi: 10.1007/s00394-025-03694-x.ABSTRACTPURPOSE: Chronic intakes of functional foods (probiotics, apples and oats) have been reported to have beneficial effects on hepatic lipid regulation and glycaemic control, but mechanistic human studies humans are limited. An

Rhodopsin Induces Myopia via Lipid Peroxidation in Zebrafish Reared in a Dark Environment

FASEB J. 2025 May 15;39(9):e70612. doi: 10.1096/fj.202402612RRR.ABSTRACTOutdoor time and light intensity are important emerging factors affecting myopia; however, the underlying mechanisms remain unknown. This study aimed to clarify whether a dark environment induces myopia in zebrafish and investig

Disruption of PPARG Activity and CPT1A Regulation by Bisphenol A: Implications for Hepatic Lipid Metabolism

J Cell Mol Med. 2025 May;29(9):e70416. doi: 10.1111/jcmm.70416.ABSTRACTBisphenol A (BPA) is a widely used industrial chemical with potential endocrine-disrupting effects on metabolic processes. This study investigates the impact of BPA on hepatic function and transcriptional regulation in mouse live

Long-term dual-trajectories of TyG and LAP and their association with cardiometabolic multimorbidity in midlife: the CARDIA study

Cardiovasc Diabetol. 2025 May 9;24(1):198. doi: 10.1186/s12933-025-02761-1.ABSTRACTBACKGROUND: Insulin resistance and central obesity are major risk factors for cardiometabolic diseases. The triglyceride-glucose index (TyG) and lipid accumulation product (LAP) are markers that independently predict

Sanhuang Xiexin Decoction ameliorates lipid disorders in obese mice via inducing browning of white adipose tissue and activating brown adipose tissue

Chin Med. 2025 May 9;20(1):60. doi: 10.1186/s13020-025-01111-3.ABSTRACTBACKGROUND: Obesity has become a critical public health challenge worldwide. Prioritizing prevention and tackling root causes-rather than merely managing symptoms-is critical to curbing this pandemic. Strategies that activate and

Study on the correlation between oxidized low- density lipoprotein and oxidized high- density lipoprotein with type 2 diabetes complicated by pulmonary tuberculosis

BMC Pulm Med. 2025 May 9;25(1):225. doi: 10.1186/s12890-025-03669-y.ABSTRACTOBJECTIVES: This study aims to investigate the correlations between oxidized lipoproteins, specifically oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL), and the comorbidities of T2DM an

A cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypes

BMC Genomics. 2025 May 9;26(1):462. doi: 10.1186/s12864-025-11676-w.ABSTRACTGlucocorticoids, acting through the glucocorticoid receptor (GR), control metabolism, maintain homeostasis, and enable adaptive responses to environmental challenges. Their function has been comprehensively studied, leading

Application of the C-reactive protein-triglyceride glucose index in predicting the risk of new-onset diabetes in the general population aged 45 years and older: a national prospective cohort study

BMC Endocr Disord. 2025 May 9;25(1):126. doi: 10.1186/s12902-025-01947-8.ABSTRACTOBJECTIVE: Triglyceride-to-glucose index (TyG index) and inflammation are both independent risk factors for diabetes. However, only a few studies have combined TyG index with inflammation indices to predict diabetes ris

Human milk composition in women with gestational diabetes mellitus: a systematic review and meta-analysis

BMC Pregnancy Childbirth. 2025 May 9;25(1):549. doi: 10.1186/s12884-025-07412-7.ABSTRACTBACKGROUND: Gestational diabetes mellitus (GDM) is a prevalent pregnancy disorder. In recent years, numerous studies have affirmed the augmented risk of obesity and diabetes mellitus in the offspring of affected

Exploring the toxicological and beneficial effects of 4,5,6-Trimethoxy-2,3-diphenyl indole on Labeo rohita fingerlings

Sci Rep. 2025 May 9;15(1):16206. doi: 10.1038/s41598-025-01099-8.ABSTRACTThe aim of this research was to examine the potential toxic or beneficial impacts of 4,5,6-Trimethoxy-2,3-diphenyl indole on fingerlings of Labeo rohita when administered in water. The study involved four groups of Labeo rohita

Therapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers

Physiol Rep. 2025 May;13(9):e70348. doi: 10.14814/phy2.70348.ABSTRACTLiver transplantation is the only curative option for end-stage liver disease. Donor shortages necessitate the use of higher risk donor livers, including fatty livers, which are more susceptible to ischemia-reperfusion injury. Mach

Differential Effects of Wild Blueberry (Poly)Phenol Metabolites in Modulating Lipid Metabolism and Oxidative Stress in 3T3-L1 Adipocytes

Mol Nutr Food Res. 2025 May 9:e70101. doi: 10.1002/mnfr.70101. Online ahead of print.ABSTRACTAdipocyte hypertrophy, driven by lipid accumulation, is crucial in the development of obesity. Wild blueberry (WB; Vaccinium angustifolium) (poly)phenols (PPs) metabolites may modulate adipogenesis and the d

The independent association between changes in physical activity participation time and dyslipidemia risk

Nutr Metab Cardiovasc Dis. 2024 Dec 3:103815. doi: 10.1016/j.numecd.2024.103815. Online ahead of print.ABSTRACTBACKGROUND AND AIM: This study aimed to examine the independent association between changes in participation time across different types of physical activities and dyslipidemia.METHODS AND

Molecular targets of bempedoic acid and related decoy fatty acids

Trends Endocrinol Metab. 2025 May 8:S1043-2760(25)00077-3. doi: 10.1016/j.tem.2025.04.002. Online ahead of print.ABSTRACTDisorders of lipid metabolism, including hyperlipidemia, atherosclerosis, and metabolic dysfunction-associated steatotic liver disease, are increasing across the globe. Bempedoic

Metabolomic profiles underlying gout flares: a prospective study of people with gout

RMD Open. 2025 May 8;11(2):e005278. doi: 10.1136/rmdopen-2024-005278.ABSTRACTOBJECTIVES: To identify specific metabolomic profiles associated with gout flares in people with gout.METHODS: Participants with gout were sequentially enrolled. In cross-sectional analysis, data were analysed according to

Metabolic syndrome among a Ghanaian cohort living with HIV initiated on dolutegravir in a real-world setting: a prospective study

BMJ Open. 2025 May 8;15(5):e097340. doi: 10.1136/bmjopen-2024-097340.ABSTRACTOBJECTIVES: The use of antiretroviral therapy has been linked to the development of some components of metabolic syndrome (MetS), specifically glucose intolerance, weight gain and defective lipid metabolism. This study dete

Plaat1 deficiency reduces cardiac cardiolipin content and impairs exercise tolerance

Phospholipase A and acyltransferase 1 (PLAAT1) catalyzes O-transacylase, N-transacylase and phospholipase A(1/2) reactions. We have demonstrated that PLAAT1 has O-transacylase activity in vitro using phosphatidylcholine as an acyl donor, and monolysocardiolipin (MLCL) as an acyl acceptor, generating

Global deletion of COX-2 Attenuates Hepatic Inflammation but Impairs Metabolic Homeostasis in Diet-Induced Obesity

J Lipid Res. 2025 May 7:100823. doi: 10.1016/j.jlr.2025.100823. Online ahead of print.ABSTRACTThe role of cyclooxygenase-2 (COX-2), a well-known pharmacological target for attenuating inflammation, in regulating obesity and its co-morbidities remains unclear. We sought to determine the role of COX-2

Effect of probiotic supplementation on glycemic control in patients with type 2 diabetes: a randomized controlled trial

Clin Nutr ESPEN. 2025 May 7:S2405-4577(25)00310-9. doi: 10.1016/j.clnesp.2025.05.013. Online ahead of print.ABSTRACTBACKGROUND: Type 2 diabetes presents significant public health challenges. The gut microbiome has emerged as a potential factor influencing glucose metabolism.METHODS: We performed a r

Loss of Plxdc2 exacerbates microglia-mediated neuroinflammation and ischemic brain injury

Exp Neurol. 2025 May 7:115302. doi: 10.1016/j.expneurol.2025.115302. Online ahead of print.ABSTRACTMicroglia are the supervisors maintaining intracerebral homeostasis, which function importantly in determining the outcome of ischemic stroke. Plxdc2 is a single-transmembrane protein and mainly studie

Impacts and mechanism of liver-specific knockout of selenoprotein I on hepatic phospholipid metabolism, selenogenome expression, redox status, and resistance to CCl(4) toxicity

Free Radic Biol Med. 2025 May 7:S0891-5849(25)00662-8. doi: 10.1016/j.freeradbiomed.2025.05.387. Online ahead of print.ABSTRACTSelenoprotein I (SELENOI) was known initially as ethanolamine phosphotransferase 1 (EPT1) and later as a selenoprotein. Because global knockout of Selenoi in mice is embryon

Metabolomics Changes After Exercise Intervention Reveal Potential Peripheral Biomarkers in Repeated Methamphetamine Exposure

Physiol Behav. 2025 May 7:114944. doi: 10.1016/j.physbeh.2025.114944. Online ahead of print.ABSTRACTMethamphetamine (MA) use disorder has become a global public health problem, and the peripheral mechanisms underlying exercise as a potential treatment for MA addiction are still not fully understood.

Mechanisms and Applications of Apolipoproteins and Apolipoprotein Mimetic Peptides: Common Pathways in Cardiovascular Disease and Cancer

Semin Cancer Biol. 2025 May 7:S1044-579X(25)00057-4. doi: 10.1016/j.semcancer.2025.05.006. Online ahead of print.ABSTRACTApolipoproteins are the defining functional component of lipoproteins and play critical roles in lipid transport and metabolism. High-density lipoprotein (HDL) and its primary fun

Dehydrozingerone ameliorates renal structure compromised in diabetic nephropathy

Biochim Biophys Acta Mol Basis Dis. 2025 May 7:167894. doi: 10.1016/j.bbadis.2025.167894. Online ahead of print.ABSTRACTKidney structural integrity is critical for bodily excretory mechanism. Diabetes has been considered as one of the major risk factors for chronic kidney disease, but the underlying