Functional analysis of intron 3 in the regulation of gene expression of the human lipoprotein lipase gene

Cell Mol Biol (Noisy-le-grand). 2025 Jul 6;71(6):34-43. doi: 10.14715/cmb/2025.71.6.5.ABSTRACTLipoprotein lipase (LPL) is a key enzyme that hydrolyzes triglycerides (TGs) into free fatty acids. Several genetic variants of LPL are directly or indirectly associated with variations in lipid levels, cau

MicroRNAs at the crossroads of exercise and ferroptosis: a regulatory bridge

Clin Exp Med. 2025 Jul 6;25(1):234. doi: 10.1007/s10238-025-01766-0.ABSTRACTFerroptosis is a unique form of regulated cell death characterized by iron-dependent lipid peroxidation. MicroRNAs (miRNAs) are pivotal in modulating ferroptosis by targeting essential molecules, including SLC7A11, GPX4, ACS

Palmitic acid-induced autolysosomal dysfunction and lipotoxicity in neuroinflammation and neurodegeneration

Neural Regen Res. 2025 Jul 5. doi: 10.4103/NRR.NRR-D-25-00432. Online ahead of print.ABSTRACTNeurodegenerative disorders such as Alzheimer's and Parkinson's diseases are increasingly associated with metabolic dysfunction, including obesity, type 2 diabetes, and metabolic dysfunction-associated steat

Tanshinone IIA induces ferroptosis in colorectal cancer cells through the suppression of SLC7A11 expression via the PI3K/AKT/mTOR pathway

Eur J Med Res. 2025 Jul 5;30(1):576. doi: 10.1186/s40001-025-02842-7.ABSTRACTBACKGROUND: Colorectal cancer (CRC) is a malignant tumor of the digestive system with high incidence rate and mortality. Tanshinone IIA (Tan IIA) plays an anti-cancer role in a variety of cancer cells. Here, we aimed to elu

Reprogramming of liver metabolism during West Nile virus infection unveils novel aspects of disease pathophysiology

Mol Med. 2025 Jul 5;31(1):251. doi: 10.1186/s10020-025-01300-8.ABSTRACTBACKGROUND: West Nile virus (WNV) is a neurotropic mosquito-borne flavivirus responsible for outbreaks of encephalitis and meningitis worldwide. About 20% of infected patients exhibit abnormal liver function tests, although the p

MiR-30d-5p Modulates Glucose and Lipid Metabolism by Targeting CD73 through the AMPK Pathway

Cell Biochem Biophys. 2025 Jul 5. doi: 10.1007/s12013-025-01815-1. Online ahead of print.ABSTRACTType 2 diabetes (T2D) involves disrupted metabolism and immune responses, but mechanisms remain unclear. This study examines CD73 and its potential regulation by miR-30d-5p via the AMPK pathway. In db/db

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily

Nat Commun. 2025 Jul 5;16(1):6213. doi: 10.1038/s41467-025-61633-0.ABSTRACTOuter membrane proteins (OMPs) define the surface biology of Gram-negative bacteria, with roles in adhesion, transport, catalysis and signalling. Specifically, porin beta-barrels are common diffusion channels, predominantly m

Multi-omics reveals the synergistic mechanism of polymyxin B and diethyldithiocarbamate against Pseudomonas aeruginosa

Int J Antimicrob Agents. 2025 Jul 3:107569. doi: 10.1016/j.ijantimicag.2025.107569. Online ahead of print.ABSTRACTResistance to polymyxin B (PMB) in carbapenem-resistant Pseudomonas aeruginosa (CRPA) has become a global issue. A promising approach to rescue PMB treatment failures is to repurpose non

In Vitro Dynamics of Oyster Hemocytes in Plasma-Based Primary Cultures

Exp Cell Res. 2025 Jul 3:114662. doi: 10.1016/j.yexcr.2025.114662. Online ahead of print.ABSTRACTHemocytes are specialized cells found in the circulatory system of invertebrates, such as marine bivalves, and play crucial roles in physiology and health. However, in bivalves, in-depth studies on their

A ROS/ultrasound dual-responsive nanocarrier enhances drug penetration for ameliorating metabolic dysfunction-associated steatohepatitis

Acta Biomater. 2025 Jul 3:S1742-7061(25)00503-3. doi: 10.1016/j.actbio.2025.07.010. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatohepatitis (MASH), as a chronic inflammatory liver disease, presents a significant challenge for effective drug delivery due to excess extracellular

Polystyrene Microplastics and 17α-Methyltestosterone Induce Sphingolipid Metabolic Disruption, Leading to Liver and Brain Damage via the Liver-Brain Axis in Zebrafish (Danio rerio)

Free Radic Biol Med. 2025 Jul 3:S0891-5849(25)00810-X. doi: 10.1016/j.freeradbiomed.2025.07.006. Online ahead of print.ABSTRACTGlobally, approximately 80% of wastewater is discharged into aquatic environments without proper treatment, introducing hazardous compounds into ecosystems. Pollutant intera

Guanosine enhances thermogenesis and impairs KEAP1-mediated NRF2 degradation to resist ferroptosis in brown adipose tissue

Free Radic Biol Med. 2025 Jul 3:S0891-5849(25)00807-X. doi: 10.1016/j.freeradbiomed.2025.07.003. Online ahead of print.ABSTRACTBrown adipose tissue (BAT) is the primary site of non-shivering thermogenesis, playing a crucial role in the regulation of glucose and lipid metabolism, as well as energy ba

Effectiveness and safety of the SREBP1/2 inhibitor, fatostatin, in a preclinical model of metabolic dysfunction-associated steatotic liver disease progression

Eur J Pharmacol. 2025 Jul 3:177890. doi: 10.1016/j.ejphar.2025.177890. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disorder that can progress to metabolic dysfunction-associated steatohepatitis (MASH), potentially leading to liv

Fatty acid nitroalkenes regulate intestinal lipid absorption

Fatty acid nitroalkenes (NO(2)-FA) are tissue-protective and anti-inflammatory endogenous lipid mediators. A unique electrophilic character promotes reversible reactions with protein thiols, influencing key cellular functions. Given their generation during digestion and therapeutic potential, unders

Functional characterization of genetic variants affecting the intracellular domains of ATP-binding cassette transporter A1 (ABCA1)

J Lipid Res. 2025 Jul 3:100854. doi: 10.1016/j.jlr.2025.100854. Online ahead of print.ABSTRACTThe ATP-binding cassette transporter A1 (ABCA1) effluxes cellular cholesterol and phospholipids to extracellular acceptors, mainly apolipoprotein A1, generating high density lipoprotein (HDL) particles. Thi

Insights to phytochemistry, analytical methods, pharmacological activities, stability, and specifications of alantolactone

Fitoterapia. 2025 Jul 3:106716. doi: 10.1016/j.fitote.2025.106716. Online ahead of print.ABSTRACTAlantolactone, a sesquiterpene lactone derived from plants of the Asteraceae family, has been extensively studied for its diverse pharmacological potential. Research suggests that various biochemical pat

Effect of Central UAG on Metabolic Associated Fatty Liver Disease: a Possible Mechanism involving in GLP-1 Neural Pathway

Peptides. 2025 Jul 3:171427. doi: 10.1016/j.peptides.2025.171427. Online ahead of print.ABSTRACTOBJECTIVE: The study aimed to investigate the possible effect of central unacylated ghrelin (UAG) on metabolic associated fatty liver disease (MAFLD) and its underlying mechanism.METHODS: A high fat diet

Involvement of oxidative stress, lipid dysmetabolism and gut microbiol dysbiosis in oxaliplatin-induced fatty liver disease: evidence from a tree shrew model

Clin Res Hepatol Gastroenterol. 2025 Jul 3:102645. doi: 10.1016/j.clinre.2025.102645. Online ahead of print.ABSTRACTBACKGROUND: Oxaliplatin is cornerstone treatment for colorectal cancer, yet a significant proportion of patients develop drug-induced fatty liver disease (DILI). How it induces such li

Calycosin-7-O-beta-D-glucoside alleviates non-alcoholic fatty liver disease by regulating short-chain fatty acids metabolism and metabolic regulators

J Nutr Biochem. 2025 Jul 3:110018. doi: 10.1016/j.jnutbio.2025.110018. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a metabolic stress liver injury disease caused by excessive fat deposition in hepatocytes. Astragalus memeranaceus Fisch., mainly consists of flavonoids,

Linking lipidomics to meat quality: A review on texture and flavor in livestock and poultry

Food Chem. 2025 Jun 30;492(Pt 1):145402. doi: 10.1016/j.foodchem.2025.145402. Online ahead of print.ABSTRACTThis review explores the application of lipidomics in livestock and poultry meat research, focusing on lipid identification and analysis from the perspectives of meat quality and flavor. We of

SCD1 protects acinar cells from ferroptosis during severe acute pancreatitis by balancing lipid and redox homeostasis

Int Immunopharmacol. 2025 Jul 4;162:115171. doi: 10.1016/j.intimp.2025.115171. Online ahead of print.ABSTRACTDuring severe acute pancreatitis (SAP), the circulating free fatty acid levels are elevated, and this elevation correlates with a poor prognosis. However, the precise mechanisms by which lipi

High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

Cell Rep. 2025 Jul 3;44(7):115947. doi: 10.1016/j.celrep.2025.115947. Online ahead of print.ABSTRACTMYCN amplification, a characteristic of aggressive neuroblastoma, presents therapeutic challenges. This study uncovered the potential effects of a fructose metabolite, acetate, on the transcriptional

FBXO10 inhibits ferroptosis and promotes the progression of esophageal squamous cell carcinoma by post-translational mediation of ACSL4 degradation

J Mol Histol. 2025 Jul 5;56(4):214. doi: 10.1007/s10735-025-10497-1.ABSTRACTFerroptosis, a regulated cell death mechanism characterized by iron dependency and lipid peroxidation, has been identified as a pivotal driver of tumor evolution and treatment resistance. Our findings reveal a previously unr

The Role of Lysyl Oxidase in the Pathological Stage of Atherosclerosis: Structural Stabilizer or Disease Driver?

Curr Atheroscler Rep. 2025 Jul 5;27(1):69. doi: 10.1007/s11883-025-01312-z.ABSTRACTPURPOSE OF REVIEW: Atherosclerosis (AS) is a progressive disease characterized by initial lipid deposition, endothelial dysfunction, inflammation, fibrocalcific lesions formation, and ultimately, plaque instability in