Differential gene expression in skeletal muscle in response to variation in diet quality consumed by pregnant mature angus cows

J Anim Sci. 2026 Feb 3:skag021. doi: 10.1093/jas/skag021. Online ahead of print.ABSTRACTThe objectives of this study were to evaluate the effect of diet type on feed intake, animal performance and intake rank in mature, gestating Angus cows (130 ± 13 days pregnant at trial initiation) and to identif

Liver specific-inhibition of LPCAT3 ameliorates metabolic dysfunction-associated steatotic liver disease

J Mol Med (Berl). 2026 Feb 3;104(1):39. doi: 10.1007/s00109-026-02648-y.ABSTRACTThe membrane unsaturation in the liver is associated with abnormal biosynthesis and accumulation of cholesterol and triglycerides, which is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD).

NRZ complex facilitates virus infection via enhancing ER-LD contacts

J Cell Biol. 2026 Mar 2;225(3):e202506149. doi: 10.1083/jcb.202506149. Epub 2026 Feb 3.ABSTRACTLipid droplets (LDs), originating from the ER, play critical roles in lipid metabolism. ER-LD contacts enable lipid exchange and support essential cellular processes. However, how viruses utilize ER-LD coo

Research advancements on dietary bioactive compounds ameliorating lipid deposition mechanisms via autophagy regulation

Food Funct. 2026 Feb 3. doi: 10.1039/d5fo04520g. Online ahead of print.ABSTRACTThe core pathological basis of obesity and its associated metabolic diseases is excessive lipid deposition. Bioactive compounds from dietary resources, such as polyphenols and flavonoids, can significantly improve lipid h

Blackcurrant Anthocyanin Supplementation Alters Exercise-Induced Substrate Utilization - A Systematic Review and Meta-Analysis

J Diet Suppl. 2026 Feb 3:1-16. doi: 10.1080/19390211.2026.2624114. Online ahead of print.ABSTRACTBlackcurrant anthocyanins have been investigated for their effects on exercise‑induced substrate utilisation. Previous research has examined the influence of supplementation dose, duration, and exercise

Biochemical Profiles of Three Bryophytes: Sphagnum papillosum, Rhytidiadelphus triquetrus, and Ditrichum gracile

Chem Biodivers. 2026 Feb;23(2):e02757. doi: 10.1002/cbdv.202502757.ABSTRACTThis study compared Sphagnum papillosum, Rhytidiadelphus triquetrus, and Ditrichum gracile in terms of total phenolic content (TPC), total flavonoid content (TFC), antioxidant activities (DPPH, ABTS, ferric reducing antioxida

CR2-fH, A Targeted Inhibitor of Alternative Complement Pathway Reduces Dry AMD-Like Phenotype in AMD Patient iPSC-derived RPE Cells

Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):9. doi: 10.1167/iovs.67.2.9.ABSTRACTPURPOSE: To investigate whether the alternative pathway (AP) of complement inhibition restores the epithelial phenotype and ameliorates dry AMD biomarkers in AMD patient induced pluripotent stem cell-derived RPE (iPSC-RP

The role of batokines in metabolism and their therapeutic potential

Expert Rev Endocrinol Metab. 2026 Feb 3:1-9. doi: 10.1080/17446651.2026.2624400. Online ahead of print.ABSTRACTINTRODUCTION: Interlinkage between lipid and carbohydrate metabolism remains a key focus of research into the pathogenesis and novel management of obesity-related conditions like Type 2 Dia

Mechanistic insights into the cholesterol-lowering activity of γ-oryzanol components

Food Funct. 2026 Feb 3. doi: 10.1039/d5fo03394b. Online ahead of print.ABSTRACTγ-Oryzanol, a mixture of phytosteryl ferulates present in rice bran, has gained attention for its cholesterol-lowering properties, likely due to its interaction with the pharmacological target enzyme 3-hydroxy-3-methyl-gl

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Alzheimers Dement. 2026 Feb;22(2):e71083. doi: 10.1002/alz.71083.ABSTRACTINTRODUCTION: Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD.METHODS: Li

Molecular characterizations and functional analyses of the novel salivary effector SaApo AI from the cereal aphid Sitobion avenae

Pest Manag Sci. 2026 Feb 2. doi: 10.1002/ps.70606. Online ahead of print.ABSTRACTBACKGROUND: Salivary proteins are 'scouts' in plant-herbivore interactions, influencing plant immune responses and insect fitness. Apolipoproteins, a kind of lipid metabolism-associated proteins, have been repeatedly fo

Association between the modified cardiometabolic index and asthma among participants in the United States: A cross-sectional NHANES analysis

Medicine (Baltimore). 2026 Jan 30;105(5):e47444. doi: 10.1097/MD.0000000000047444.ABSTRACTThe modified cardiometabolic index (MCMI) integrates key cardiometabolic factors that drive airway inflammation in asthma through abnormal adipokine secretion, lipid disorders, and impaired glucose metabolism.

Association between ketogenic diet and cognitive function in older adults: The mediating role of neutrophil to high-density lipoprotein cholesterol ratio

Medicine (Baltimore). 2026 Jan 30;105(5):e47441. doi: 10.1097/MD.0000000000047441.ABSTRACTThe ketogenic diet (KD), characterized by high fat and low carbohydrate intake, has shown potential neuroprotective effects, but its association with cognitive function in older adults and the underlying mechan

Psoralidin, a main compound in Psoraleae Fructus, induces hepatotoxicity by impeding lipid oxidative catabolism and aggravating lipid accumulation in mice

Chin Med. 2026 Feb 2;21(1):58. doi: 10.1186/s13020-026-01335-x.ABSTRACTBACKGROUND: Psoralea corylifolia(PF) is widely utilized for the treatment of conditions such as kidney yang deficiency, frequent urination, and cold pain in the waist and knees. However, both basic research and clinical reports i

The HKDC1-ASS1-ACSBG2 axis reprograms lipid metabolism to drive therapeutic resistance in hepatocellular carcinoma

No abstractJ Transl Med. 2026 Feb 3. doi: 10.1186/s12967-026-07779-x. Online ahead of print.NO ABSTRACTPMID:41629949 | DOI:10.1186/s12967-026-07779-x

In vitro evidence and integrative bioinformatics identify the SGLT2-PPARγ axis as a target against polyethylene microplastic-driven metabolic reprogramming in colorectal cancer cells

J Transl Med. 2026 Feb 2. doi: 10.1186/s12967-026-07776-0. Online ahead of print.ABSTRACTBACKGROUND: Microplastics have emerged as a growing burden to human health, with increasing evidence linking chronic exposure to adverse outcomes including inflammation, metabolic disruption, and carcinogenesis.

JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms

Leukemia. 2026 Feb 2. doi: 10.1038/s41375-025-02843-9. Online ahead of print.ABSTRACTHypoxia-inducible factors (HIFs) are master transcriptional regulators, central to cellular survival in hypoxia and frequently activated within malignancy. Whilst malignant context directs the role of HIFs within on

ER remodelling is a feature of ageing and depends on ER-phagy

Nat Cell Biol. 2026 Feb 2. doi: 10.1038/s41556-025-01860-1. Online ahead of print.ABSTRACTThe endoplasmic reticulum (ER) comprises an array of subdomains, each defined by a characteristic structure and function. Although altered ER processes are linked to age-onset pathogenesis, it is unclear whethe

Cholecystectomy inhibits fasting hepatic fatty acid oxidation in mice

Commun Biol. 2026 Feb 2. doi: 10.1038/s42003-026-09621-y. Online ahead of print.ABSTRACTCholecystectomy is associated with an increased risk of metabolic syndrome (MetS); however, the underlying mechanism remains unknown. The gallbladder acts as a storage organ for hepatic bile and regulates the fee

Gut microbiota-derived butyrate primes systemic immunity in honey bees by mediating lipid metabolic reprogramming

Nat Commun. 2026 Feb 2. doi: 10.1038/s41467-026-69073-0. Online ahead of print.ABSTRACTThe gut microbiota plays a crucial role in insect immune priming, inducing enhanced immune response that functionally resembles acquired immunity confined to vertebrates. While gut microbiota mediates systemic imm

Untargeted 1H NMR-based metabolomics unveils distinct circulating biochemical signatures between treatment-resistant and non-treatment-resistant schizophrenia patients: a pilot study

Transl Psychiatry. 2026 Feb 2. doi: 10.1038/s41398-026-03853-6. Online ahead of print.ABSTRACTSchizophrenia is a severe psychiatric disorder that affects approximately 1% of the population. Despite the availability of antipsychotic therapies, about 30% of patients develop treatment-resistant schizop

Wnt-associated DKK3 in keratinocytes mediates radiation-induced hyperplasia, dermatitis and skin fibrosis

Signal Transduct Target Ther. 2026 Feb 2;11(1):41. doi: 10.1038/s41392-025-02541-z.ABSTRACTRadiotherapy remains a mainstay of cancer treatment. However, radiotherapy can also elicit acute and chronic adverse effects, including dermal inflammation and skin fibrosis. A comprehensive understanding of t

Band-Selective IR PRESS for Brain Tumor Spectroscopy Allows Robust Detection of Lactate

NMR Biomed. 2026 Mar;39(3):e70220. doi: 10.1002/nbm.70220.ABSTRACTLactate plays a critical role in the tumor microenvironment, driving tumor progression, metastasis, and immune evasion. Despite its importance, in vivo quantification of lactate using magnetic resonance spectroscopy (MRS) has faced ch

The fungal biocontrol agent Beauveria bassiana expresses a HsbA domain-containing protein to postpone the rapid cuticle penetration outwards from the insect cadavers

Pestic Biochem Physiol. 2026 Mar;218:106958. doi: 10.1016/j.pestbp.2026.106958. Epub 2026 Jan 14.ABSTRACTThe insect biocontrol fungi (IBF) 'hidden' within the dead insect bodies come out of the insect cadavers for dissemination until the suitable environment conditions arising. However, details of t