Comprehensive Investigation on the Influence of Dietary Soybean Oil Levels in a Soybean Oil-Based Diet on Gibel Carp (Carassius gibelio): Insights Regarding Growth, Nutrition, and Physiological, Metabolic, and Transcriptomic Analyses

Aquac Nutr. 2026 Sep 29;2026:9199711. doi: 10.1155/anu/9199711. eCollection 2026.ABSTRACTFive isonitrogenous (35%) diets with different lipid contents were prepared by adding 0%, 3%, 6%, 9%, and 12% soybean oil (SO) as the single lipid source (with groups designated SO0, SO3, SO6, SO9, and SO12, res

Lactobacillus plantarum and Bacillus licheniformis Ameliorate High-Carbohydrate-High-Fat-Induced Glycolipid Disorders in Common Carp in Association With the Gut Microbiota and Bile Acid Axis

Aquac Nutr. 2026 Sep 29;2026:6145147. doi: 10.1155/anu/6145147. eCollection 2026.ABSTRACTHigh-carbohydrate-high-fat (HCHF) diets help reduce feed costs in intensive aquaculture, but they often induce glycolipid metabolic disorders and hepatopancreatic steatosis in farmed fish. Although probiotics ha

Gut microbiota-host co-metabolism in hypertriglyceridemia-associated acute pancreatitis: from causality to precision intervention

Front Immunol. 2026 Sep 16;17:1932634. doi: 10.3389/fimmu.2026.1932634. eCollection 2026.ABSTRACTClinical outcomes in hypertriglyceridemia-associated acute pancreatitis remain highly heterogeneous. Despite comparable lipid burdens, patients may experience anything from mild interstitial edema to ful

Ferroptosis in retinal neurodegeneration: mechanistic vulnerability, therapeutic targeting, and translational barriers

Front Med (Lausanne). 2026 Sep 16;13:1890483. doi: 10.3389/fmed.2026.1890483. eCollection 2026.ABSTRACTProgressive retinal neurodegeneration remains a major therapeutic challenge in ophthalmology because structural and functional loss may continue despite control of the primary insult, including int

Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities

Biochem Biophys Rep. 2026 Sep 18;48:102798. doi: 10.1016/j.bbrep.2026.102798. eCollection 2026 Dec.ABSTRACTMajor depressive disorder (MDD) is a heterogeneous psychiatric disorder involving oxidative stress, neuroinflammation, mitochondrial dysfunction, impaired neuroplasticity, and metabolic dysregu

Polyunsaturated fatty acids and psychotic disorders: integrating mechanistic, genetic, and clinical evidence

Front Nutr. 2026 Sep 16;13:1929742. doi: 10.3389/fnut.2026.1929742. eCollection 2026.ABSTRACTPolyunsaturated fatty acids (PUFAs), including omega-3 (n-3) and omega-6 (n-6) essential fatty acids, play critical roles in brain development and function, serving as precursors to a wide range of bioactive

Long-term metabolic consequences of in-utero gestational diabetes exposure and maternal treatment interventions: a systematic review and meta-analysis

Front Endocrinol (Lausanne). 2026 Sep 16;17:1904624. doi: 10.3389/fendo.2026.1904624. eCollection 2026.ABSTRACTBACKGROUND: Gestational diabetes mellitus (GDM) affects 14-17% of pregnancies globally, imposing long-term public health burdens beyond pregnancy. Maternal hyperglycaemia increases offsprin

Chocolate Processed by Extrusion Cooking Affects Glucose and Lipid Metabolism in Humans: A Randomized, Double-Blind, Crossover Trial

Food Sci Nutr. 2026 Sep 30;14(10):e72409. doi: 10.1002/fsn3.72409. eCollection 2026 Oct.ABSTRACTPromoting positive and well-being-centered eating behavior in humans has recently garnered considerable attention. If the postprandial metabolic response of nutrients, especially sugars that are deleterio

Clinical study on the combined use of cardiovascular agents and statins in the treatment of coronary heart disease

Pak J Med Sci. 2026 Sep;42(9):2422-2427. doi: 10.12669/pjms.42.9.16299.ABSTRACTOBJECTIVE: To evaluate the clinical efficacy of combining cardiovascular agents with statins in the treatment of coronary heart disease(CHD).METHODOLOGY: This was a retrospective study. A total of 110 patients diagnosed w

MAFLD is linked to lower HBV DNA levels in chronic hepatitis B: clinical and transcriptomic insights

Front Med (Lausanne). 2026 Sep 16;13:1926645. doi: 10.3389/fmed.2026.1926645. eCollection 2026.ABSTRACTBACKGROUND: Chronic hepatitis B (CHB) frequently coexists with metabolic dysfunction-associated fatty liver disease (MAFLD), yet the impact of MAFLD on hepatitis B virus (HBV) replication remains i

A defined microbial community remodels host metabolism and pathogen resistance in Caenorhabditis elegans

bioRxiv [Preprint]. 2026 Sep 9:2026.09.06.749774. doi: 10.64898/2026.09.06.749774.ABSTRACTThe microbiome is an important regulator of metabolism and health, yet the mechanisms by which microbial communities influence host physiological state remain incompletely understood. Here we used a defined hos

P. aeruginosa liquid-based pathogenesis triggers HLH-30-dependent metabolic rewiring in C. elegans

bioRxiv [Preprint]. 2026 Sep 7:2026.09.03.749215. doi: 10.64898/2026.09.03.749215.ABSTRACTInnate immunity is the first line of defense against invading pathogens and is essential for maintaining host survival. While the majority of innate immunity studies have focused on pathogen recognition and ant

Inflammatory Proteomic Network Architecture of Visceral Adiposity and Cardiometabolic Traits

Res Sq [Preprint]. 2026 Sep 28:rs.3.rs-11156776. doi: 10.21203/rs.3.rs-11156776/v1.ABSTRACTBackground : Visceral adipose tissue (VAT) is strongly associated with cardiometabolic disease, but the network architecture connecting visceral adiposity to systemic inflammatory proteins and cardiometabolic

Distinct lipid mediator profiles in brain and liver tissues in Alzheimer's disease

medRxiv [Preprint]. 2026 Sep 23:2026.09.22.26363708. doi: 10.64898/2026.09.22.26363708.ABSTRACTINTRODUCTION: Inflammation plays a central role in Alzheimer's Disease (AD), with oxylipins, endocannabinoids, and polyunsaturated fatty acids (PUFAs) acting as potent modulators. Soluble epoxide hydrolase

Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants

bioRxiv [Preprint]. 2026 Sep 12:2026.09.08.750261. doi: 10.64898/2026.09.08.750261.ABSTRACTAlzheimer's disease (AD) is the most prevalent neurodegenerative disorder, and its incidence is rising rapidly with population aging. Pathologically, AD is characterized by the accumulation of amyloid-β (Aβ) p

Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries

bioRxiv [Preprint]. 2026 Sep 25:2026.09.20.753049. doi: 10.64898/2026.09.20.753049.ABSTRACTArteries are among the first tissues to exhibit age-related dysfunction, yet the metabolic mechanisms driving vascular senescence remain poorly understood. Here, analysis of human aortic transcriptomic data id

A phytocannabinoid-sensitive phosphorylation switch converts endocannabinoids into alternative lipid GPCR activators

Endocannabinoids (eCBs) like anandamide and 2-arachidonoylglycerol are endogenous lipid ligands for CB (1) and CB (2) G protein-coupled receptors (GPCRs). Here, we show that phosphorylation of biologically important anandamide generates naturally occurring anandamide phosphate (AEAp), which switches

Caloric restriction drives age-dependent and integrated remodeling of RNA processing and lipid composition in mouse brain

bioRxiv [Preprint]. 2026 Sep 22:2026.09.18.752764. doi: 10.64898/2026.09.18.752764.ABSTRACTCaloric restriction (CR) extends lifespan and delays the onset of age-related diseases. Prior work has established numerous pathways that respond to CR, including growth signaling, metabolism, and inflammatory

Sex-specific metabolic regulation by the Drosophila RNA-binding protein Nab2

bioRxiv [Preprint]. 2026 Sep 27:2026.09.25.754360. doi: 10.64898/2026.09.25.754360.ABSTRACTConserved RNA binding proteins (RBPs) regulate key steps of gene expression including mRNA processing, export, localization, stability and translation. Human ZC3H14 is a conserved RBP that regulates pre-mRNA p

Morphine causes distinct changes in the lipidome throughout the brain and body after acute or chronic administration: implications for novel endogenous lipid signaling systems involved in opioid reward and withdrawal

bioRxiv [Preprint]. 2026 Sep 23:2026.09.17.752401. doi: 10.64898/2026.09.17.752401.ABSTRACTA growing body of evidence demonstrates that signaling pathways of endogenous lipids (endolipids) modulate the reinforcing properties of opioids including reward and withdrawal. Many of these studies are focus

ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells

bioRxiv [Preprint]. 2026 Sep 22:2026.09.21.753265. doi: 10.64898/2026.09.21.753265.ABSTRACTBACKGROUND/OBJECTIVE: Aldehyde dehydrogenase 2 (ALDH2), a mitochondrial enzyme, mitigates cellular stress by detoxifying reactive aldehydes produced during alcohol exposure and endogenous metabolic processes.

Stromal innervation is prognostic in non-muscle-invasive bladder cancer and predicted by a distinct microenvironmental transcriptomic signature

bioRxiv [Preprint]. 2026 Sep 22:2026.09.21.751588. doi: 10.64898/2026.09.21.751588.ABSTRACTPeripheral nerves are increasingly recognized as active components of the tumor microenvironment (TME). Yet, their role in non-muscle-invasive bladder cancer (NMIBC) and response to Bacillus Calmette-Guérin (B

Neuropeptides NLP-10 and FLP-18 stimulate lipid catabolism in chronically diet-restricted Caenorhabditis elegans

bioRxiv [Preprint]. 2026 Sep 23:2026.09.17.752367. doi: 10.64898/2026.09.17.752367.ABSTRACTNeuropeptides mediate inter-tissue communication in energy metabolism, yet most remain functionally uncharacterized. Using C. elegans , we uncover a neuropeptide signaling cascade that drives lipid catabolism

Ferroptosis-Targeted Strategies to Counter Hypoxia- and Acidosis-Associated Immunosuppression in the Tumor Microenvironment

Cell Reprogram. 2026 Oct 1:21524971261493449. doi: 10.1177/21524971261493449. Online ahead of print.ABSTRACTImmunotherapy has transformed cancer treatment, yet its efficacy in solid tumors remains constrained by primary or acquired resistance. Increasing evidence suggests that ferroptosis sensitivit