Duhuo Jisheng Decoction Mitigates Intervertebral Disc Degeneration via Metabolic Reprogramming and TGF-β/Smad-Driven Autophagy-Fibrosis Network Modulation

Biomed Chromatogr. 2026 Aug;40(8):e70530. doi: 10.1002/bmc.70530.ABSTRACTDuhuo Jisheng Decoction (DHJSD) shows promise for treating intervertebral disc degeneration (IVDD), but its mechanisms concerning autophagy and fibrosis are unclear. Using network pharmacology, metabolomics, UHPLC-Q-TOF/MS, and

HyperDC: A Non-Uniform Hypergraph Framework for Dual- and Higher-Order Drug Combination Recommendation Across Diverse Complex Diseases

J Chem Inf Model. 2026 Jul 1. doi: 10.1021/acs.jcim.6c01470. Online ahead of print.ABSTRACTComplex diseases are commonly characterized by dysregulation across multiple targets and pathways, making drug combinations an important therapeutic strategy. This creates a growing need for computational meth

Mechanical movements generated by movable lipids break endosomal barriers for enhanced mRNA therapeutics

Sci Adv. 2026 Jul 3;12(27):eaef1695. doi: 10.1126/sciadv.aef1695. Epub 2026 Jul 1.ABSTRACTLipid nanoparticles (LNPs), composed of ionizable lipids, phospholipids, cholesterol, and PEGylated lipids, have been successfully used in messenger RNA (mRNA) vaccine development. Despite substantial progress,

Pachymic acid alleviates circadian rhythm disorders in high-fat diet-induced obesity mice via the sphingolipid pathway

PLoS One. 2026 Jul 1;21(7):e0352604. doi: 10.1371/journal.pone.0352604. eCollection 2026.ABSTRACTBACKGROUND: Obesity caused by a high-fat diet (HFD) is known to disrupt metabolic homeostasis and circadian rhythms. Pachymic acid (PA), a bioactive triterpenoid, exhibits anti-inflammatory, antihypergly

Dual salt bridges govern proton gating and calcium leak in BsYetJ across bilayers and live cells

Proton-coupled ion transport is a fundamental chemical process underlying membrane physiology, yet how local electrostatics are transduced into gated Ca^(2+) permeation remains poorly defined. Here, we combine single-channel planar bilayer electrophysiology, nanodisc-based double electron-electron r

A genome-wide screen identifies that PLCG2 restrains lysosomal GCase activity

Proc Natl Acad Sci U S A. 2026 Jul 7;123(27):e2514112123. doi: 10.1073/pnas.2514112123. Epub 2026 Jul 1.ABSTRACTMutations in the GBA1 gene, which encodes the lysosomal glucocerebrosidase enzyme GCase, cause the lysosomal storage disorder Gaucher disease and represent the most common genetic risk fac

Linking shelter conditions to health: A multisystem analysis of stress, metabolism, and fecal microbiota in dogs

PLoS One. 2026 Jul 1;21(7):e0350401. doi: 10.1371/journal.pone.0350401. eCollection 2026.ABSTRACTVariations in space allocation and husbandry practices can significantly affect the health and welfare of long-term shelter dogs. This study compared adrenal, metabolic, and microbiological health indica

Agmatine and N-hydroxypipecolic acid synergistically enhance salt tolerance in wheat through antioxidant defense, proline metabolism, and photosynthetic protection

Plant Signal Behav. 2026 Dec 31;21(1):2696140. doi: 10.1080/15592324.2026.2696140. Epub 2026 Jul 1.ABSTRACTSalt stress severely limits wheat growth by disturbing photosynthesis, osmotic balance, and cellular redox homeostasis. This study evaluated whether agmatine and N-hydroxy pipecolic acid, appli

A high-fat, high-sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin-deficient mice

J Physiol. 2026 Jul 1. doi: 10.1113/JP289832. Online ahead of print.ABSTRACTDuchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by dystrophin deficiency and characterized by progressive muscle wasting. DMD is frequently accompanied by obesity and insulin resistance (IR); howeve

NCAPG reprograms glycolytic and lipid metabolism by sustaining glycerophospholipid flux in small-cell lung cancer

Mol Cell Biochem. 2026 Jul 1. doi: 10.1007/s11010-026-05616-9. Online ahead of print.ABSTRACTSmall-cell lung cancer (SCLC) is characterized by rapid growth and a pronounced neuroendocrine phenotype, accompanied by marked metabolic plasticity. Although metabolic reprogramming is a hallmark of SCLC, t

Sinomenine protects against oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury through regulating the myocyte enhancer factor 2 A/C-X-C motif chemokine ligand 14 pathway

J Bioenerg Biomembr. 2026 Jul 1;58(1):35. doi: 10.1007/s10863-026-10111-3.ABSTRACTAtherosclerosis (AS) is a chronic vascular disease characterized by inflammatory response and lipid deposition in the arterial walls caused by endothelial injury. Sinomenine (SIN) could delay AS progression by attenuat

Lipid reprogramming of stratified squamous epithelium by the high-risk HPV E6 and E6/E7 oncoproteins

Metabolomics. 2026 Jul 1;22(4):111. doi: 10.1007/s11306-026-02498-2.ABSTRACTINTRODUCTION: High risk human papillomavirus (HPV) infection and genome integration with pronounced expression of the viral E6/E7 oncogenes is the major cause of cervical cancer. Emerging evidence suggests that HPV reprogram

GPx6 downregulation drives ferroptosis in Kashin-Beck disease chondrocytes via the SLC7A11/GPx4 axis

Apoptosis. 2026 Jul 1;31(7):181. doi: 10.1007/s10495-026-02389-w.ABSTRACTKashin-Beck disease (KBD) is an endemic osteoarthropathy characterized by chondrocyte death and extracellular matrix (ECM) degradation; however, the underlying molecular mechanisms remain poorly understood. This study aimed to

The effect of hypoprolactinemia on cardiometabolic effects of rosuvastatin in men: A matched Cohort Pilot Study

Pituitary. 2026 Jul 1;29(4):113. doi: 10.1007/s11102-026-01721-6.ABSTRACTPURPOSE: Low prolactin levels are associated with an increased risk of vascular and metabolic diseases. Women with prolactin deficiency appear to have attenuated responses to lipid-lowering and insulin-sensitizing medications.

Interplay between ischemia-reperfusion and metabolic reprogramming

Apoptosis. 2026 Jul 1;31(7):182. doi: 10.1007/s10495-026-02392-1.ABSTRACTA common pathological process associated with acute organ injury, which is closely connected to metabolic reprogramming, is ischemia-reperfusion injury (IRI). Ischemia leads to decreased oxygen and substrate availability, with

Unanswered questions on palmitic acid-driven neuroimmune inflammation in atopic dermatitis: a commentary on Chen et al

Inflamm Res. 2026 Jul 1;75(1):163. doi: 10.1007/s00011-026-02319-1.ABSTRACTThis commentary provides a critical appraisal of the recent study by Chen and colleagues, which demonstrated that cutaneous palmitic acid (PA) aggravates atopic dermatitis (AD) by driving S-palmitoylation of transient recepto

A lipid droplet-targeted fluorescent probe for selective imaging of cysteine fluctuations in drug-induced liver injury

Anal Methods. 2026 Jul 1. doi: 10.1039/d6ay01001f. Online ahead of print.ABSTRACTCysteine (Cys), an essential endogenous biothiol, plays crucial roles in cellular redox homeostasis, metabolic regulation, and detoxification. Abnormal Cys fluctuations are closely associated with various pathological p

m6A-Modified KLF11 Inhibits Macrophage Foam Cell Formation by Transcriptionally Suppressing ATP5B Expression in Atherosclerosis

FASEB J. 2026 Jul 15;40(13):e72105. doi: 10.1096/fj.202501525RR.ABSTRACTMacrophage foam cell formation is the mark of atherosclerosis (AS). Krüppel-like factor (KLF)11 prevented the development of AS in diabetic conditions. However, it is not clear whether KLF11 inhibits macrophage foam cell formati

Cholesterol-Lowering Treatment Blocks Epithelial-Mesenchymal Transition (EMT) Associated Invasiveness and Drug Resistance in Breast and Colorectal Adenocarcinoma Models

Cancer Med. 2026 Jul;15(7):e72070. doi: 10.1002/cam4.72070.ABSTRACTBACKGROUND: Epithelial-mesenchymal transition (EMT) is a cellular process involved in the invasion and metastasis of cancer cells. Deregulated cellular cholesterol is associated with treatment resistance and metastatic potential in c

Multiomics Integration Reveals AFB1 Causes Liver Damage Involving the Gut-Microbiota-Lipid Metabolism Axis in Piglet

J Agric Food Chem. 2026 Jul 1. doi: 10.1021/acs.jafc.5c17707. Online ahead of print.ABSTRACTProlonged exposure to aflatoxin B1 (AFB1) poses a significant threat to livestock production. The liver is the main target, but the role of the gut-liver axis and lipid metabolism in pig hepatic toxicity is n

The Impact of Monocyte-to-HDL Ratio and Triglyceride-Glucose Index on Arterial Stiffness in Hemodialysis Patients

Ther Apher Dial. 2026 Jul 1. doi: 10.1002/1744-9987.70180. Online ahead of print.ABSTRACTBACKGROUND: Arterial stiffness is an important cardiovascular risk marker in hemodialysis patients. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and triglyceride-glucose (TyG) index are labor

ApoE- and Cfh-deficient mice exhibit structural and molecular features of human early-intermediate retinal degeneration

CONCLUSIONS: The ApoE^(-/-)Cfh^(-/-) mouse reproduces key molecular and structural features of early and intermediate retinal degeneration with statistically significant alterations. Although it does not progress to advanced disease stages, it represents a valuable model to investigate several facto

Nitrate and resveratrol supplementation selectively enhances hepatic adaptations to aerobic exercise in high-fat fed male mice

Am J Physiol Endocrinol Metab. 2026 Jul 1. doi: 10.1152/ajpendo.00529.2025. Online ahead of print.ABSTRACTAerobic exercise training (AET) and numerous dietary interventions, including nitrate and resveratrol supplementation, display overlapping mechanisms affecting mitochondrial bioenergetics and me

Hyperhomocysteinemia promotes lipid deposition in skeletal muscle

Front Neurol. 2026 Jun 16;17:1861632. doi: 10.3389/fneur.2026.1861632. eCollection 2026.ABSTRACTBACKGROUND: Lipid storage myopathy (LSM) is characterized by abnormal lipid accumulation in skeletal muscle. Emerging evidence suggests that environmental factors, including the use of antidepressants suc