Transcriptomic analysis reveals the regulatory role of LIPE in lipid metabolism and tumor-associated macrophage polarization in breast cancer

Pathol Res Pract. 2026 May 16;284:156515. doi: 10.1016/j.prp.2026.156515. Online ahead of print.ABSTRACTBACKGROUND: Breast cancer (BC) is one of the most common malignancies in women. Lipase E, hormone-sensitive type (LIPE), is a key lipase with potential regulatory roles in tumor lipid metabolism a

Multi-dimensional analyses unveil strain-specific metabolic perturbations and flavour deterioration traits induced by spoilage bacteria in cold-stored chicken breast

Int J Food Microbiol. 2026 May 15;457:111849. doi: 10.1016/j.ijfoodmicro.2026.111849. Online ahead of print.ABSTRACTThis study aimed to explore the spoilage mechanisms and flavour deterioration characteristics of cold-stored chicken breast induced by three typical psychrotrophic spoilage bacteria Br

Nanomedicine-enabled ferroptosis intervention:from antitumor effects to immune remodeling in lung diseases

Biomaterials. 2026 May 12;334:124301. doi: 10.1016/j.biomaterials.2026.124301. Online ahead of print.ABSTRACTFerroptosis, a regulated cell death (RCD) process driven by iron-dependent lipid peroxidation, has emerged as a pivotal focus in recent therapeutic research for lung diseases. This comprehens

EDL6D, a bioactive peptide phenocopying SHBG-associated metabolic effects: a new preclinical lead compound for treating the metabolic dysfunction-associated fatty liver disease

J Transl Med. 2026 May 16. doi: 10.1186/s12967-026-08305-9. Online ahead of print.ABSTRACTBACKGROUND: Low plasma sex hormone-binding globulin (SHBG) levels are commonly observed in metabolic dysfunction-associated fatty liver disease (MASLD), a spectrum of disorders ranging from simple hepatocellula

Metabolic status in mothers with gestational diabetes mellitus and the effects on fetal and neonatal outcomes - a cohort study

BMC Pregnancy Childbirth. 2026 May 16. doi: 10.1186/s12884-026-09170-6. Online ahead of print.ABSTRACTBACKGROUND: Research on gestational diabetes mellitus has mainly focused on glucose metabolism, but improving glycemic control has not eliminated the complication rate in these pregnancies. The aim

Effects of ensiling temperature on fermentation quality, enzyme activities, and metabolomic profiles in Pediococcus acidilactici L10-inoculated native grass silage

BMC Plant Biol. 2026 May 16. doi: 10.1186/s12870-026-08941-9. Online ahead of print.ABSTRACTIn cold regions, the efficient preservation of native grass is often constrained by low temperatures during the ensiling process. This study investigated the fermentation quality, enzyme activity patterns, an

CTMP-REV7 axis modulates MHC-I antigen presentation via CDK1-AKT crosstalk in MSI-L/MSS colorectal cancer

Cell Oncol (Dordr). 2026 May 16. doi: 10.1007/s13402-026-01222-5. Online ahead of print.ABSTRACTPURPOSE: Microsatellite instability-low/microsatellite stable (MSI-L/MSS) colorectal cancer (CRC) exhibits limited responsiveness to immune checkpoint inhibitors due to low tumor mutational burden and ins

Arylacetamide deacetylase attenuates hepatic lipid accumulation under ER stress conditions by regulating iron-dependent oxidative stress

Toxicol Appl Pharmacol. 2026 May 15:117872. doi: 10.1016/j.taap.2026.117872. Online ahead of print.ABSTRACTArylacetamide deacetylase (AADAC) is a drug-metabolizing enzyme that catalyzes the hydrolysis of clinical drugs containing an acetyl moiety. Recent in vitro studies have suggested that AADAC al

Sex and Wolbachia endosymbiont modulate lipid profiles in terrestrial isopod Armadillidium vulgare

J Invertebr Pathol. 2026 May 15:108651. doi: 10.1016/j.jip.2026.108651. Online ahead of print.ABSTRACTMost eukaryotic organisms live in close association with microorganisms known as symbionts, which influence host evolution, physiology, and ecosystem functioning. Among these, Wolbachia pipientis, a

Metabolism-modulating nanoparticles for remodeling adipose-liver crosstalk to reverse liver fibrosis

J Control Release. 2026 May 15:115026. doi: 10.1016/j.jconrel.2026.115026. Online ahead of print.ABSTRACTThe interplay between adipose tissue and liver becomes dysregulated during liver fibrogenesis. Despite its importance, the adipose-liver axis remains overlooked, limiting the efficacy of current

Roles of Rho GTPases in Adipocyte Differentiation, Insulin Signaling and Lipid Droplet Dynamics

J Nutr. 2026 May 15:101597. doi: 10.1016/j.tjnut.2026.101597. Online ahead of print.ABSTRACTRho GTPases, a family of small GTPases, are important players in many physiological processes such as cytoskeleton remodeling. Emerging experimental results have indicated them as pivotal regulators of lipid

The effects of a powdered meal replacement intake on inflammation, gut microbiota, and metabolism compared to habitual diet in people with excess body weight - results from a randomized controlled trial

J Nutr. 2026 May 15:101595. doi: 10.1016/j.tjnut.2026.101595. Online ahead of print.ABSTRACTBACKGROUND: Excess body weight is associated with chronic low-grade inflammation and metabolic abnormalities, such as insulin resistance, and dyslipidemia.OBJECTIVE: This study aimed to assess the impact of a

Metabolic-circadian reprogramming mediates epithelial barrier destabilization during Euphorbia fischeriana toxicity and its mitigation by traditional milk processing

J Ethnopharmacol. 2026 May 15:121861. doi: 10.1016/j.jep.2026.121861. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: EUPHORBIAE EBRACTEOLATAE RADIX (Langdu), the dried root of Euphorbia fischeriana Steud. (E. fischeriana), has been widely used in Mongolian and traditional Chinese medi

Zinc modulates metallothionein remodeling and lipid metabolism in human epithelial cells under inflammatory stress

J Nutr Biochem. 2026 May 15:110416. doi: 10.1016/j.jnutbio.2026.110416. Online ahead of print.ABSTRACTZinc deficiency and chronic low‑grade inflammation are prevalent conditions that compromise epithelial integrity and metabolic homeostasis, particularly in ageing populations. Here, we investigated

Cassava-resistant starch type 3 modulates high-fat diet-induced adiposity and transcriptional oxidative stress imbalance

Nutr Res. 2026 Apr 21;150:139-156. doi: 10.1016/j.nutres.2026.04.006. Online ahead of print.ABSTRACTHigh-fat diets (HFDs) are associated with excessive weight gain and lipid accumulation, contributing to metabolic syndrome. Resistant starch (RS), an indigestible dietary fiber that undergoes colonic

Cold acclimation promotes the fatty acid desaturation and glycerophospholipid metabolism of the visceral adipose tissue in the Schizothorax prenanti

Fish Physiol Biochem. 2026 May 16;52(3):76. doi: 10.1007/s10695-026-01695-z.ABSTRACTAdipose tissue functions as a metabolic energy source, supporting fish growth, reproduction, embryonic development, and swimming. However, the metabolic changes of adipose tissue in cold-water fish under cold acclima

Comparative evaluation of zinc hydroxychloride and zinc sulphate on growth performance, antioxidant status, immune function, and zinc bioavailability in growing crossbred calves

Vet Res Commun. 2026 May 16;50(4):328. doi: 10.1007/s11259-026-11257-6.ABSTRACTZinc (Zn) is an essential trace mineral involved in antioxidant defense, immune regulation, and metabolic processes in livestock. Hydroxy trace minerals such as zinc hydroxychloride (ZnOHCl) have gained attention due to t

Oculomics of lipid metabolism: A scoping review across anterior and posterior segment diseases

Sci Prog. 2026 Apr-Jun;109(2):368504261453276. doi: 10.1177/00368504261453276. Epub 2026 May 16.ABSTRACTDyslipidemia comprises interacting disturbances in lipids and lipoproteins that track with metabolic status, vascular biology, and inflammation. Ocular imaging offers scalable, quantifiable phenot

A Bidirectional Association Between Helicobacter pylori Infection and Hyperlipidemia: Clinical Evidence and Mechanistic Insights

Helicobacter. 2026 May-Jun;31(3):e70135. doi: 10.1111/hel.70135.ABSTRACTBACKGROUND AND AIMS: Helicobacter pylori is a persistent gastric microbe with systemic consequences beyond the stomach, yet its contribution to host lipid dysregulation remains unclear.METHODS: We analyzed clinical data from 57,

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells

J Neurochem. 2026 May;170(5):e70454. doi: 10.1111/jnc.70454.ABSTRACTGlioblastoma (GB) is the most malignant form of human brain tumor, characterized by heterogeneous cell populations, including undifferentiated cells defined as GB stem cells (GSCs), responsible for initiating the neoplastic process

Physiological role and application potential of HcCAT2 in multi-host adaptability of Hyphantria cunea revealed by RNA interference

Insect Mol Biol. 2026 May 15. doi: 10.1111/imb.70042. Online ahead of print.ABSTRACTThe antioxidant defence system is crucial for herbivorous insects to adapt to various host plants. This study focused on catalase 2 gene (HcCAT2) to investigate the antioxidant mechanisms that underlie the ability of

Sophora tonkinensis Alleviates Progression of Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats via Multitarget Regulation

Biomed Chromatogr. 2026 Jul;40(7):e70486. doi: 10.1002/bmc.70486.ABSTRACTSophora tonkinensis, a traditional Chinese medicine with heat-clearing, detoxifying, and throat-soothing properties, has shown potential in treating hepatitis, inhibiting tumors, and regulating immunity, but its active constitu

Construction of a predictive model for the risk of non-alcoholic fatty liver disease in patients with sleep apnea syndrome based on multiple machine learning algorithms: a multicenter study

BMC Med Inform Decis Mak. 2026 May 15. doi: 10.1186/s12911-026-03547-5. Online ahead of print.ABSTRACTBACKGROUND: Sleep apnea syndrome (SAS) is closely related to an increased risk of non-alcoholic fatty liver disease (NAFLD), but current clinical tools lack the integration of multidimensional data

Noninvasive early detection and grading of pneumoconiosis via plasma proteomics and machine learning: PRSS3 as a potential biomarker

Clin Proteomics. 2026 May 15. doi: 10.1186/s12014-026-09591-7. Online ahead of print.ABSTRACTBACKGROUND: Coal-dust, a persistent airborne pollutant, induces dose-related pulmonary fibrosis; however, plasma biomarkers for pre-clinical toxicity remain lacking.METHODS: We enrolled 158 participants, inc