Food Funct. 2025 Sep 5. doi: 10.1039/d5fo01459j. Online ahead of print.ABSTRACTThis study investigated the advantages of gerbils as a sympathetic nervous system (SNS)-driven model for non-alcoholic fatty liver disease (NAFLD) and evaluated the therapeutic potential of soy isoflavones (SIFs). Gerbils
Int J Mol Med. 2025 Nov;56(5):180. doi: 10.3892/ijmm.2025.5621. Epub 2025 Sep 5.ABSTRACTAtherosclerosis is a chronic and progressive vascular disease involving the gradual accumulation of lipids, cholesterol, cellular debris, and fibrous elements within the arterial wall. This process leads to the t
Autophagy Rep. 2025 Sep 2;4(1):2551028. doi: 10.1080/27694127.2025.2551028. eCollection 2025.ABSTRACTThe autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional Atg9
Front Microbiol. 2025 Aug 20;16:1625098. doi: 10.3389/fmicb.2025.1625098. eCollection 2025.ABSTRACTObesity significantly impacts the health and economy of modern society, and the prevention and treatment of obesity is a key focus of social research. The main reason for obesity is the excessive accum
Front Nutr. 2025 Aug 20;12:1619371. doi: 10.3389/fnut.2025.1619371. eCollection 2025.ABSTRACTOBJECTIVE: Obstructive sleep apnea (OSA) is associated with glucose and lipid disturbances and insulin resistance. However, glucose and lipid disturbances and insulin resistance in OSA are often attributed t
Res Sq [Preprint]. 2025 Aug 27:rs.3.rs-7014857. doi: 10.21203/rs.3.rs-7014857/v1.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. Disruptions in iron metabolism and mitochondrial oxidative function may cooperatively contribut
Res Sq [Preprint]. 2025 Aug 27:rs.3.rs-7421061. doi: 10.21203/rs.3.rs-7421061/v1.ABSTRACTThe divergence between the central and peripheral vascular system, particularly the emergence of the blood-brain barrier (BBB), is central to the brain's homeostasis and functions. However, the molecular and gen
bioRxiv [Preprint]. 2025 Aug 28:2025.08.22.671845. doi: 10.1101/2025.08.22.671845.ABSTRACTDysregulation in lipid metabolism is increasingly recognized as a key contributor to age-related diseases, including neurodegeneration and cerebrovascular dysfunction. While prior studies have largely focused o
bioRxiv [Preprint]. 2025 Aug 25:2025.08.25.672169. doi: 10.1101/2025.08.25.672169.ABSTRACTSpatiotemporal environmental variation results in marked heterogeneity in bacterial infection progression and disease outcome, with vital consequences for treatment success. For the globally important pathogen
Front Genet. 2025 Aug 20;16:1619911. doi: 10.3389/fgene.2025.1619911. eCollection 2025.ABSTRACTBACKGROUND AND PURPOSE: In recent years, research on the relationship between hepatitis B virus-related cirrhosis (HBV-LC) and gut microbiota has grown, but studies focusing on the Northwest Chinese popula
Eur Heart J Case Rep. 2025 Aug 9;9(9):ytaf389. doi: 10.1093/ehjcr/ytaf389. eCollection 2025 Sep.ABSTRACTBACKGROUND: While advances in technology and procedural techniques have significantly improved outcomes post-PCI, two pharmacological strategies have gained particular attention for their effectiv
Front Cell Infect Microbiol. 2025 Aug 20;15:1629901. doi: 10.3389/fcimb.2025.1629901. eCollection 2025.ABSTRACTBACKGROUND: The intestinal microbiota composition has been linked to neurocognitive impairment in people with HIV (PWH). However, the potential interplay of microbial species and related me
Front Physiol. 2025 Aug 20;16:1633468. doi: 10.3389/fphys.2025.1633468. eCollection 2025.ABSTRACTFerroptosis is a new type of cell death driven by iron-dependent phospholipid peroxidation, which is regulated by a variety of factors including redox homeostasis, iron metabolism, lipid metabolism, cell
Aquac Nutr. 2025 Aug 27;2025:5521491. doi: 10.1155/anu/5521491. eCollection 2025.ABSTRACTTo investigate the most effective feeding level for red-tail catfish (Hemibagrus wyckioides) raised in land-based circular tanks and the impact of feeding levels on H. wyckioides at the molecular and omics level
Clin Physiol Funct Imaging. 2025 Sep;45(5):e70028. doi: 10.1111/cpf.70028.ABSTRACTThe present study investigates the relationship between obesity and metabolic, hormonal, and clinical indicators in adolescent girls. A total of 75 girls aged 15-19 years (mean age: 17.53 ± 1.29 years) were enrolled, i
Endocr Metab Immune Disord Drug Targets. 2025 Sep 1. doi: 10.2174/0118715303391165250828111133. Online ahead of print.ABSTRACTINTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease and seriously threatens children's health. Fortunellin exerts a protecti
Endocrinol Diabetes Metab. 2025 Sep;8(5):e70078. doi: 10.1002/edm2.70078.ABSTRACTBACKGROUND: Lipid accumulation product (LAP) index is a measure of lipid toxicity based on triglyceride and waist circumference. The aim of the current study is to explore the relationship between LAP index and metaboli
Adv Sci (Weinh). 2025 Sep 4:e05356. doi: 10.1002/advs.202505356. Online ahead of print.ABSTRACTFerroptosis, characterized by iron-dependent lipid peroxidation, is a form of oxidative cell death increasingly recognized for its role in cancer therapy. The susceptibility of cancer cells to ferroptosis
J Clin Lipidol. 2025 Aug 6:S1933-2874(25)00358-7. doi: 10.1016/j.jacl.2025.08.006. Online ahead of print.ABSTRACTBACKGROUND: Indigenous Australians have an increased risk of type 2 diabetes mellitus (T2DM) and premature cardiovascular disease. Subpopulations of high-density lipoprotein (HDL) have be
Int J Biol Macromol. 2025 Sep 2:147257. doi: 10.1016/j.ijbiomac.2025.147257. Online ahead of print.ABSTRACTOvarian cancer remains the deadliest gynecological malignancy, with cisplatin resistance being a major therapeutic challenge. This study investigates the role of heme oxygenase-1 (HO-1) in cisp
RGPR-p117 is a newly discovered transcription factor that specifically binds to the nuclear factor I consensus motif, TTGGC(N)(6)CC, in the promoter region of the regucalcin gene. This gene plays a multifunctional role in cell regulation. The human RGPR-p117 gene comprises 26 exons totaling approxim
Int J Biol Macromol. 2025 Sep 2:147298. doi: 10.1016/j.ijbiomac.2025.147298. Online ahead of print.ABSTRACTChronic excessive alcohol consumption leads to alcohol-associated liver disease(ALD), and its pathogenesis mechanism is related to abnormal autophagy caused by excess alcohol. However, the regu
Drug Discov Today. 2025 Sep 2:104464. doi: 10.1016/j.drudis.2025.104464. Online ahead of print.ABSTRACTLiquid-liquid phase separation (LLPS), a phenomenon characterized by a membrane-free structure formed by weak multivalent interactions of intracellular biological macromolecules, has attracted wide
Gene. 2025 Sep 2:149752. doi: 10.1016/j.gene.2025.149752. Online ahead of print.ABSTRACTCapsaicin (CAP), a major natural functional component in chili peppers, has garnered considerable attention for its health benefits, including lipid-lowering effects, and its precise mechanisms remain unclear. Th
