Lecithin-cholesterol acyltransferase promotes hepatic steatosis through fatty acid metabolism in zebrafish larvae

FEBS J. 2026 Aug 17. doi: 10.1111/febs.70706. Online ahead of print.ABSTRACTLecithin-cholesterol acyltransferase (LCAT), the key enzyme in reverse cholesterol transport (RCT), has been traditionally recognized for playing roles in high-density lipoprotein (HDL) maturation and systemic cholesterol ho

Comparison of THP-1 Subtypes Reveals Differences on Transcriptomic and Protein Expression Level Throughout Their Immunological Differentiation

J Immunol Res. 2026;2026(1):e9427482. doi: 10.1155/jimr/9427482.ABSTRACTIntensive usage of cancer cell lines as cellular model system in cancer research caused the generation of variant subtypes during the last decades. Genetic aberrations, altered transcriptomic profiles as well as changed protein

Electroacupuncture Ameliorates Scopolamine-Induced Dry Eye Disease in Mice by Restoring Lacrimal Gland Lipid Homeostasis and Reducing IL-1beta/IL-18 Expression

J Immunol Res. 2026;2026(1):e5191118. doi: 10.1155/jimr/5191118.ABSTRACTDry eye disease (DED) can lead to severe eye discomfort, which manifests as dryness, pain and decreased vision, and significantly affects daily life. This study elucidated the effects of electroacupuncture (EA) intervention on D

An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline

Aging Cell. 2026 Aug;25(8):e70671. doi: 10.1111/acel.70671.ABSTRACTAdipose tissue senescence is increasingly recognized as a key driver of systemic aging and age-related functional decline, yet the endocrine regulators that actively promote this process remain poorly defined. Angiopoietin-like prote

Spatial Engineering of Yarrowia lipolytica for the Biosynthesis of Capsanthin

Biotechnol J. 2026 Aug;21(8):e70291. doi: 10.1002/biot.70291.ABSTRACTCapsanthin is a high-value tetraterpenoid widely utilized in the food, cosmetic, and pharmaceutical industries. However, its traditional production via plant extraction and chemical synthesis faces severe sustainability and cost co

Structural bases of the conformational transitions of the mitochondrial choline carrier SLC25A48 captured by molecular dynamics simulations

Int J Biol Macromol. 2026 Aug 16:154090. doi: 10.1016/j.ijbiomac.2026.154090. Online ahead of print.ABSTRACTThe mitochondrial choline carrier SLC25A48 mediates choline import into the mitochondrial matrix, supporting one‑carbon metabolism and epigenetic regulation. Despite its physiological relevanc

Rotavirus-NSP5 interacts with and hijacks host ATP citrate lyase to viroplasms, enhancing lipid biosynthesis for facilitating rotavirus infection

Virulence. 2026 Dec 31;17(1):2709258. doi: 10.1080/21505594.2026.2709258. Epub 2026 Aug 16.ABSTRACTRotavirus (RV) replication occurs within viroplasms (VMs) and is initiated by two RV non-structural proteins NSP2 and NSP5. Viruses exploit host cellular components for their replication and assembly;

Exogenous kinetin mitigates arsenic-induced oxidative stress by regulating ROS homeostasis and antioxidant defense in Ocimum basilicum L

Plant Cell Rep. 2026 Aug 16;45(9):246. doi: 10.1007/s00299-026-03934-2.ABSTRACTIntegrated physiological, biochemical, histochemical, and structural analyses demonstrated that exogenous kinetin effectively alleviates arsenic-induced oxidative damage in Ocimum basilicum. Arsenic (As) contamination pos

Metabolic and muscular adaptations to dietary succinate in Tan sheep: Insights from transcriptomics

Anim Nutr. 2026 Jul 3;26:699-715. doi: 10.1016/j.aninu.2026.01.017. eCollection 2026 Sep.ABSTRACTSuccinate (SUC), a dietary feed additive, is known to influence muscle fiber structure and lipid metabolism, thereby enhancing meat quality in livestock. This study evaluated the effects of SUC supplemen

Randomized prospective trial comparing mixed oil versus soybean oil lipid emulsion: A feasibility pilot study

Intest Fail. 2026 Aug 7;12:100389. doi: 10.1016/j.intf.2026.100389. eCollection 2026 Oct-Dec.ABSTRACTBACKGROUND: Mixed-oil (MO) intravenous lipid emulsions (ILEs) are increasingly used in adults receiving home parenteral nutrition (HPN), but prospective data from United States HPN programs remain li

Advanced analytical approaches for endocannabinoids and endocannabinoid-like substances: Applications in liver disease research

J Pharm Anal. 2026 Aug;16(8):101546. doi: 10.1016/j.jpha.2026.101546. Epub 2026 Jan 5.ABSTRACTEndocannabinoids (eCBs) and eCB-like substances are lipid mediators that play vital roles in regulating diverse physiological and pathological processes. These effects are predominantly mediated through int

Metabolomic profiling of HepG2/C3A liver-on-chip model exposed to oleic acid, palmitic acid and oleic/palmitic acids mixture

NAM J. 2026 Jul 30;2:100122. doi: 10.1016/j.namjnl.2026.100122. eCollection 2026.ABSTRACTMetabolic dysfunction associated steatotic liver disease (MASLD) is one of the most predominant liver disorders. MASLD is associated with dietary intake of fatty acids. Among them, oleic (OA) and palmitic (PA) a

Deciphering synergistic killing mechanisms of capsaicin combined with colistin against colistin-resistant Acinetobacter baumannii through metabolomics analysis

Biochem Biophys Rep. 2026 Aug 7;47:102740. doi: 10.1016/j.bbrep.2026.102740. eCollection 2026 Sep.ABSTRACTColistin is increasingly used as last-line therapy for A. baumannii infections. This has led to the emergence of colistin-resistant strains of A. baumannii. Therefore, exploring novel approaches

Metabolic reprogramming in pancreatic cancer: interplay of glucose, lipid, and amino acid metabolism in tumor progression

Cytotechnology. 2026 Oct;78(5):179. doi: 10.1007/s10616-026-01052-1. Epub 2026 Aug 14.ABSTRACTPancreatic cancer is one of the most malignant solid tumors, with a five-year survival rate of less than 10%. The therapeutic challenges primarily stem from difficulties in early diagnosis, high heterogenei

Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis

Cell Death Differ. 2026 Aug 15. doi: 10.1038/s41418-026-01846-y. Online ahead of print.ABSTRACTEffector regulatory T (eTreg) cells are indispensable for maintaining peripheral immune tolerance and can also interfere with antitumor immunity. However, how epigenetic modifications regulate eTreg differ

Fer-1 improves cognitive dysfunction in chronic kidney disease through the Sirt2/PGC-1α signaling pathway based on RNA sequencing

Exp Neurol. 2026 Aug 15:115958. doi: 10.1016/j.expneurol.2026.115958. Online ahead of print.ABSTRACTFerroptosis is a non-apoptotic form of cell death characterized by cellular accumulation of iron-dependent lipid peroxidation. In recent years, a series of studies have proved that ferroptosis partici

Cluster of Differentiation 36-Engineered Photosynthetic Cyanobacteria Enable Immunometabolic Reprogramming in Triple-Negative Breast Cancer

Acta Biomater. 2026 Aug 15:S1742-7061(26)00557-X. doi: 10.1016/j.actbio.2026.08.025. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) exhibits profound resistance to immunotherapy, largely due to a tumor microenvironment constrained by dysregulated lipid metabolism and persistent h

Vascular Complications: Mechanisms and Therapeutic Perspectives

Pharmacol Res. 2026 Aug 15:108388. doi: 10.1016/j.phrs.2026.108388. Online ahead of print.ABSTRACTDiabetic vascular complications are a major determinant of poor prognosis in diabetic patients, with their development closely linked to persistent low-grade inflammation. Macrophages, as key regulatory

Metabolomic signatures and sex-specific associations of prenatal per- and polyfluoroalkyl substances exposure with fetal growth: A meet-in-the-middle and high-dimensional mediation analysis

Environ Int. 2026 Aug 14;215:110461. doi: 10.1016/j.envint.2026.110461. Online ahead of print.ABSTRACTBACKGROUND: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with restricted fetal growth. However, the underlying biological mechanisms remain unclear.METHODS: Ba

Generation of a human induced pluripotent stem cell line (HEBHMUi019-A) from a 67-year-old male Alzheimer's patient with APOE-ε4/ε4 genotype

Stem Cell Res. 2026 Aug 13;95:104082. doi: 10.1016/j.scr.2026.104082. Online ahead of print.ABSTRACTApolipoprotein E (apoE), encoded by the polymorphic APOE gene, plays a key role in lipid transport and metabolism. The three major APOE alleles are ε2, ε3, and ε4, with ε4 being the strongest genetic

Transcriptomic insights into the coordinated regulation of signaling, apoptosis, immunity, and metabolism during Sinonovacula constricta larval metamorphosis

Comp Biochem Physiol Part D Genomics Proteomics. 2026 Aug 14;60:101977. doi: 10.1016/j.cbd.2026.101977. Online ahead of print.ABSTRACTMetamorphosis is a critical ontogenetic transition for marine bivalves, marking the shift from planktonic to benthic lifestyles, where successful transformation dicta

Extracellular vesicle lipidomics for disease diagnostics and mechanism-informed discovery

Curr Opin Biotechnol. 2026 Aug 15;101:103570. doi: 10.1016/j.copbio.2026.103570. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are cell-released nanoparticles whose lipid membranes enclose molecular cargo and contribute to vesicle stability, uptake, and biological activity. EV compositi

Biological and metabolism responses of earthworm (Eisenia fetida) exposed to metribuzin

Ecotoxicol Environ Saf. 2026 Aug 15;323:120665. doi: 10.1016/j.ecoenv.2026.120665. Online ahead of print.ABSTRACTMetribuzin, a widely used triazine herbicide, has been extensively studied for its toxic effects on aquatic organisms, but its impact on soil organisms, particularly earthworms, remains i

Hsd3b7 regulates ovarian development and maturation via steroidogenesis and lipid metabolism in Qihe gibel carp (Carassius gibelio var. Qihe)

Anim Reprod Sci. 2026 Aug 13;293:108310. doi: 10.1016/j.anireprosci.2026.108310. Online ahead of print.ABSTRACTSteroid hormones regulate ovarian development, but hsd3b7 function in fish remains unclear. In this study, we cloned full-length hsd3b7 cDNA from Qihe gibel carp (Carassius gibelio var. Qih