Epigallocatechin gallate alleviates intervertebral disc degeneration by suppressing ferroptosis-driven innate immune activation in nucleus pulposus cells

Int Immunopharmacol. 2026 Mar 29;178:116559. doi: 10.1016/j.intimp.2026.116559. Online ahead of print.ABSTRACTBACKGROUND: Intervertebral disc degeneration (IDD) is the main reason for lower back pain, it has a vicious circle that ECM degradation, inflammation, and cell death. Ferroptosis is a kind o

Construction and evaluation of an AOP framework to explore cobalt-induced nonalcoholic fatty liver disease

Ecotoxicol Environ Saf. 2026 Mar 28;314:120084. doi: 10.1016/j.ecoenv.2026.120084. Online ahead of print.ABSTRACTWith the rapid advancements of the new energy industry, cobalt demand has risen substantially, raising concerns about associated health risks. Epidemiological investigations have identifi

Fatty acid regulation of feeding in Caenorhabditis elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system

Proc Natl Acad Sci U S A. 2026 Apr 7;123(14):e2530979123. doi: 10.1073/pnas.2530979123. Epub 2026 Mar 30.ABSTRACTRegulation of food intake in mammals is complex and controlled by an interplay between hedonic and homeostatic signals, including hormones like leptin, which senses fat storage and suppre

The Crimean-Congo haemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production

Emerg Microbes Infect. 2026 Dec;15(1):2645855. doi: 10.1080/22221751.2026.2645855. Epub 2026 Mar 30.ABSTRACTThe Crimean-Congo Haemorrhagic Fever Virus (CCHFV), a tri-segmented negative-strand virus that belongs to the Orthonairovirus genus, is highly pathogenic in humans but not in other host specie

Oral supplementation of sodium butyrate prevents lipid metabolism disorders and intestinal injury by modulating immunity, intestinal barrier functions, and gut microbiota in a corticosterone-induced chronic stress model in mice

Stress Biol. 2026 Mar 30;6(1):25. doi: 10.1007/s44154-026-00289-2.ABSTRACTIn intensive livestock and poultry farming, chronic stress poses a significant threat to animal health, primarily through its impact on butyric acid levels and intestinal microbiota balance. In our previous study, we found tha

Comparative Analysis of Red Onion-Derived Exosome-Like Nanovesicles and Extract Reveals Sustained Immunomodulatory Effects in LPS/IFN-γ-Stimulated Microglia

Mol Neurobiol. 2026 Mar 30;63(1):533. doi: 10.1007/s12035-026-05820-0.ABSTRACTNeuroinflammation is a central factor in many neurodegenerative diseases, making it an important target for novel treatments. This study compares the effects of organic red onion-derived materials, particularly crude extra

Astrocytes in neuroinflammation and brain cancer

Mol Biomed. 2026 Mar 30;7(1):40. doi: 10.1186/s43556-026-00439-y.ABSTRACTAstrocytes are increasingly recognized as active regulators of glioma progression rather than passive bystanders. In addition to blood-brain barrier support, metabolic homeostasis, and synaptic regulation, astrocytes undergo st

Humoral responses against high-density lipoprotein are linked to unfavorable lipid and proteomic signatures in primary Sjogren disease-a multi-platform approach

Rheumatology (Oxford). 2026 Mar 28:keag141. doi: 10.1093/rheumatology/keag141. Online ahead of print.ABSTRACTOBJECTIVES: Immune-mediated mechanisms and altered lipid metabolism may contribute to increased cardiovascular risk in Sjögren disease (SjD). Antibodies targeting HDL have emerged as modulato

Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy

Invest Ophthalmol Vis Sci. 2026 Mar 2;67(3):60. doi: 10.1167/iovs.67.3.60.ABSTRACTPURPOSE: The degree of unsaturation in hydrocarbon chains (HCunsat) is likely to play an important role in determining the stability, order, and fluidity of lipids in the tear film lipid layer. The HCunsat of meibum li

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

FEBS J. 2026 Mar 30. doi: 10.1111/febs.70522. Online ahead of print.ABSTRACTNotch receptor activation requires γ-secretase-mediated release of Notch intracellular domain 1 (NICD1) to regulate gene transcription. Here, we identify the proton-driven solute carrier 11a2 (Slc11a2) or divalent metal tran

Long-chain fatty acid homeostasis contributes to survival of uropathogenic E. coli during copper toxicity

J Bacteriol. 2026 Mar 30:e0011726. doi: 10.1128/jb.00117-26. Online ahead of print.ABSTRACTUropathogenic Escherichia coli (UPEC) is the leading causative agent of urinary tract infection (UTI). Copper (Cu) is a host effector mobilized to the bladder during the innate immune response activated by acu

Unveiling conserved and breed-specific RNA expression signatures underlying hepatic homoeostasis across genetically diverse chicken breeds

Br Poult Sci. 2026 Mar 30:1-12. doi: 10.1080/00071668.2026.2621259. Online ahead of print.ABSTRACT1. The liver plays a key role in lipid metabolism, immune regulation and energy balance. To better understand the fundamental molecular mechanisms that support liver function, this study investigated he

Microbial mechanisms of rapid startup in a sequencing batch biofilm reactor treating high-ammonia slaughterhouse wastewater

Water Sci Technol. 2026 Mar;93(6):804-816. doi: 10.2166/wst.2026.242. Epub 2026 Mar 11.ABSTRACTTraditional processes for treating high-ammonia slaughterhouse wastewater face challenges of long start-up periods and poor shock load resistance. This study established a sequencing batch biofilm reactor

Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3

Acta Pharm Sin B. 2026 Mar;16(3):1510-1529. doi: 10.1016/j.apsb.2025.11.004. Epub 2025 Nov 6.ABSTRACTIn our screening campaign for novel ferroptosis inhibitors, we identified that vitamin A (VA) and its metabolite all-trans retinoic acid (ATRA) exhibited potent ferroptosis-suppressing activity. Nota

Wilforine attenuates inflammatory osteolysis by suppressing osteoclast fusion through JAK-STAT-stomatin immunoregulatory signaling

Front Immunol. 2026 Mar 13;17:1789493. doi: 10.3389/fimmu.2026.1789493. eCollection 2026.ABSTRACTBACKGROUND: Excessive osteoclast fusion and activation are central drivers of bone erosion in inflammatory osteopathies, which are closely linked to immune dysregulation. Wilforine, a natural compound, e

Establishment of Serum 25-Hydroxyvitamin D Reference Range for Healthy Adult Men Not Using Vitamin D Supplements in Alqurayyat, Saudi Arabia

Int J Gen Med. 2026 Mar 24;19:535665. doi: 10.2147/IJGM.S535665. eCollection 2026.ABSTRACTBACKGROUND: Vitamin D is a secosteroid, a lipid-soluble vitamin that is involved in various physiological responses, including skeletal metabolism and immune response. Vitamin D [25(OH)D] in the blood is also i

Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment

Bioact Mater. 2026 Mar 18;62:402-427. doi: 10.1016/j.bioactmat.2026.02.057. eCollection 2026 Aug.ABSTRACTObesity treatment is entering a new era with the advent of multifunctional nanomaterials capable of precise biological intervention. This review highlights their pivotal role in overcoming key th

Paeoniflorin protects against NAFLD through antioxidant, anti-inflammatory effects and restoration of gut microbiota homeostasis

Front Microbiol. 2026 Mar 13;17:1766068. doi: 10.3389/fmicb.2026.1766068. eCollection 2026.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a widespread chronic metabolic disorder characterized by hepatic lipid accumulation, oxidative stress, inflammation and gut dysbiosis. Paeoniflorin (PAF) ex

Supramolecular self-assembly of EGCG-cysteine nanodrugs for ferroptosis and oxidative stress inhibition in chondrocytes to treat osteoarthritis

Mater Today Bio. 2026 Mar 10;38:102978. doi: 10.1016/j.mtbio.2026.102978. eCollection 2026 Jun.ABSTRACTOsteoarthritis (OA) is a common chronic degenerative joint disease that is characterized mainly by the destruction of articular cartilage, synovial inflammation and osteophyte formation, and seriou

PPARgamma: a key orchestrator of epidermal barrier, immune responses, and lipid metabolism in atopic dermatitis pathogenesis and therapy

Front Allergy. 2026 Mar 13;7:1780908. doi: 10.3389/falgy.2026.1780908. eCollection 2026.ABSTRACTAtopic dermatitis (AD) is an immune-mediated inflammatory dermatosis characterized by epidermal barrier dysfunction, immune dysregulation, and cutaneous microbial dysbiosis. Existing therapeutic modalitie

A rapid and reliable strategy for identification of LNP and protein corona in vitro and in vivo

Int J Pharm X. 2026 Mar 17;11:100519. doi: 10.1016/j.ijpx.2026.100519. eCollection 2026 Jun.ABSTRACTThis study develops an integrated analytical method for visual verification and subsequent analysis of lipids and protein coronas of lipid nanoparticles (LNPs) in vitro and in vivo. In this strategy,

Successful GH Treatment of Hepatopulmonary Syndrome in Panhypopituitarism-related Advanced Liver Disease

JCEM Case Rep. 2026 Mar 26;4(4):luaf307. doi: 10.1210/jcemcr/luaf307. eCollection 2026 Apr.ABSTRACTHepatopulmonary syndrome (HPS) is a known pulmonary vascular complication of chronic liver disease. In rare circumstances, HPS has been described in the context of panhypopituitarism. An underlying mec

Identification of mitochondria-related key genes in type 2 diabetes mellitus and elucidation of the Zhimu-Huangbai herb Pair's mechanism: an integrated approach of bioinformatics, machine learning, and experimental validation

Front Cell Dev Biol. 2026 Mar 13;14:1763178. doi: 10.3389/fcell.2026.1763178. eCollection 2026.ABSTRACTBACKGROUND: Mitochondrial injury plays a critical role in type 2 diabetes mellitus (T2DM) pathogenesis by impairing cellular energy metabolism and insulin sensitivity. The Zhimu-Huangbai herb pair

Potential lipid-lowering effects of Coffea arabica pulp extract product in hyperlipidemia-obese subjects: a randomized double-blind placebo-controlled trial

Front Nutr. 2026 Mar 12;13:1755054. doi: 10.3389/fnut.2026.1755054. eCollection 2026.ABSTRACTBACKGROUND: Coffea arabica pulp aqueous extract (CPE) exhibits anti-hyperlipidemia, anti-hyperglycemia, and anti-inflammatory effects in vitro and in vivo. This randomized, double-blind, controlled study eva