Valve-Specific Comparative Effectiveness of Direct Oral Anticoagulants Versus Vitamin K Antagonists After Surgical Valve Procedures in Atrial Fibrillation: A Systematic Review and Meta-Analysis

Cardiol Rev. 2026 Jul 2. doi: 10.1097/CRD.0000000000001386. Online ahead of print.ABSTRACTAnticoagulation after left-sided bioprosthetic valve replacement or mitral valve repair in patients with atrial fibrillation (AF) remains uncertain, as decisions must balance prevention of thromboembolism again

Limitations of cardiac risk scores in elective non-cardiac surgeries: a Brazilian cohort

Rev Assoc Med Bras (1992). 2026 Jun 29;72(3):e20251821. doi: 10.1590/1806-9282.20251821. eCollection 2026.ABSTRACTINTRODUCTION: Surgical procedures are associated with an excess of postoperative cardiovascular events. Risk scores are used for cardiovascular stratification but lack proper validation

Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models

Sci Transl Med. 2026 Jul;18(856):eaea9877. doi: 10.1126/scitranslmed.aea9877. Epub 2026 Jul 1.ABSTRACTThe neuropeptide neurotensin (NTS) is up-regulated in cardiac lymphatic endothelial cells (LECs) in response to ischemic or mechanical damage, but its role in cardiac remodeling is unknown. Here, we

Admission NT-proBNP provides stronger prognostic discrimination than the AHEAD score for 1-year mortality in hospitalized acute heart failure: A retrospective cohort study

PLoS One. 2026 Jul 1;21(7):e0353113. doi: 10.1371/journal.pone.0353113. eCollection 2026.ABSTRACTBACKGROUND: Both admission N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the AHEAD score predict prognosis in acute heart failure, but their comparative and complementary value for admission

Synthesis and biological evaluation of aconitine-type derivatives as potential cardiotonic agents

Eighteen C(19) aconitine-type derivatives were designed and syn-thesized with the modification of core active and strong toxicity components, such as yunaconitine (YA), mesaconitine (MA), and hypaconitine (HA) in Fuzi through hydrolysis and demethylation reactions. Their structures were confirmed by

Real-world outcomes of Finerenone in patients with diabetic kidney disease in Saudi Arabia

PLoS One. 2026 Jul 1;21(7):e0352861. doi: 10.1371/journal.pone.0352861. eCollection 2026.ABSTRACTBACKGROUND: Diabetic kidney disease (DKD) represents a significant microvascular complication associated with type 2 diabetes mellitus (T2DM), markedly elevating the risk of kidney failure, cardiovascula

Guideline-recommended medical therapy and clinical outcomes in cancer patients with de Novo heart failure

Acta Cardiol. 2026 Jul 1:1-12. doi: 10.1080/00015385.2026.2664091. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Heart failure (HF) may result from cancer therapy, yet data on guideline-recommended medical therapy (GRMT) in this setting remain limited. We aimed to describe the clinical course o

The cardiorenometabolic syndrome as a new clinical paradigm in precision medicine

Arch Cardiol Mex. 2026 Jul 1. doi: 10.24875/ACM.26000037. Online ahead of print.ABSTRACTCardiorenal-metabolic syndrome (CRMS) is a pathophysiological interaction of metabolic, cardiovascular, and renal dysfunctions, sharing mechanisms such as chronic inflammation, insulin resistance, neurohormonal a

Association between red cell distribution width and all-cause mortality in patients with congestive heart failure and atrial fibrillation

Acta Cardiol. 2026 Jul 1:1-11. doi: 10.1080/00015385.2026.2695318. Online ahead of print.ABSTRACTBACKGROUND: The role of red cell distribution width (RDW) in critically ill patients with congestive heart failure (CHF) and atrial fibrillation (AF), requiring intensive care unit (ICU) admission, remai

Association of Markers of Kidney Tubular Secretion and Risk of Acute Kidney Injury after Acute Heart Failure

Kidney360. 2026 Jul 1. doi: 10.34067/KID.0000001263. Online ahead of print.ABSTRACTBACKGROUND: Acute heart failure (heart failure) is a common cause of acute kidney injury (AKI) in hospitalized patients, yet it remains unclear why some patients develop AKI while others with similar clinical courses

Kinematic-calcium loops unravel impaired excitation-contraction coupling in MELAS-affected cardioids

Impaired Ca^(2+) handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart. Phase-plane loop analysis provides an integrated assessment of excitation-contraction coupling (ECC) by capturing the dynamic relation between Ca²

First-Line Enfortumab Vedotin Plus Pembrolizumab vs Gemcitabine Plus Cisplatin for Metastatic Urothelial Carcinoma

JAMA Netw Open. 2026 Jul 1;9(7):e2621032. doi: 10.1001/jamanetworkopen.2026.21032.ABSTRACTIMPORTANCE: Enfortumab vedotin plus pembrolizumab (EV/P) recently emerged as the preferred first-line treatment regimen for metastatic urothelial carcinoma (mUC), but evidence outside trial settings is relative

Association of In-Hospital Dapagliflozin Initiation with Favorable left Ventricular Remodeling in Patients with Acute Myocardial Infarction and Heart Failure: A Retrospective Cohort Study

Cardiovasc Drugs Ther. 2026 Jul 1. doi: 10.1007/s10557-026-07904-4. Online ahead of print.ABSTRACTPURPOSE: This was a retrospective cohort study. We examined the association between in-hospital dapagliflozin initiation and left ventricular remodeling in revascularized patients with acute myocardial

Sex differences in escalation to atrioventricular node ablation following catheter ablation for atrial fibrillation

J Interv Card Electrophysiol. 2026 Jul 1. doi: 10.1007/s10840-026-02395-7. Online ahead of print.ABSTRACTBACKGROUND: Sex-based differences in atrial fibrillation (AF) symptom burden and response to rhythm control strategies are recognised. Whether female and male patients differ in escalation to atr

Serum metabolomic signatures integrating sphingosine-1-phosphate and tetrahydrocortisone improve prognostic assessment in non-ischemic cardiomyopathy

Metabolomics. 2026 Jul 1;22(4):108. doi: 10.1007/s11306-026-02497-3.ABSTRACTINTRODUCTION: Dilated cardiomyopathy (DCM) and left ventricular non-compaction (LVNC) are major non-ischemic cardiomyopathy (NICM) subtypes with heterogeneous outcomes. Conventional clinical and echocardiographic markers rem

From Cardioprotection to Trial Design: Rethinking Cardiac Safety in Oncology

Curr Heart Fail Rep. 2026 Jul 1;23(1):29. doi: 10.1007/s11897-026-00765-w.ABSTRACTPURPOSE OF REVIEW: Cardio-oncology has emerged as a pivotal discipline aimed at preserving cardiovascular health in patients undergoing contemporary cancer therapies. Despite growing awareness of treatment-related card

Copper dysregulation in cardiometabolic disease: copper deficiency versus cuproptosis

Apoptosis. 2026 Jul 1;31(7):180. doi: 10.1007/s10495-026-02390-3.ABSTRACTCopper is an essential micronutrient required for mitochondrial respiration, antioxidant defense, and metabolic homeostasis. Accumulating evidence demonstrates that dysregulated copper handling, including deficiency, redistribu

Comparative effectiveness of figure-of-eight suture and manual compression for femoral venous hemostasis after atrial fibrillation ablation: A grade assessed meta-analysis

J Thromb Thrombolysis. 2026 Jul 1. doi: 10.1007/s11239-026-03347-8. Online ahead of print.ABSTRACTAtrial fibrillation is a common cardiac arrhythmia associated with serious complications such as stroke, heart failure, and mortality. Catheter ablation is frequently used for drug-resistant cases but r

Alpha2 agonists for sedation to produce better outcomes for adults with critical illness: a synopsis of the A2B RCT with cost-effectiveness and process evaluation

Health Technol Assess. 2026 Jun;30(48):1-94. doi: 10.3310/GJTW3820.ABSTRACTBACKGROUND: Most mechanically ventilated intensive care unit patients require sedation and analgesia for comfort. Current usual care is propofol-based sedation plus an opioid analgesic. The alpha2 agonists dexmedetomidine and

The ventricular assist device outflow cannula anastomosis to the descending aorta in a patient with porcelain aorta

No abstractActa Cardiol. 2026 Jul 1:1-2. doi: 10.1080/00015385.2026.2695349. Online ahead of print.NO ABSTRACTPMID:42384063 | DOI:10.1080/00015385.2026.2695349

Alcohol consumption and the risks of morbidity and mortality across 39 diseases and conditions: A population-based cohort study in Korea

Addiction. 2026 Jul 1. doi: 10.1111/add.70518. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Alcohol is embedded in social life; however, alcohol control policies remain insufficiently enforced in Korea. Comprehensive evidence linking alcohol intake to disease and mortality is limited. This stu

Sodium-Glucose Cotransporter 2 Inhibitor Following Left Ventricular Assist Device Implantation: A Randomized Controlled Trial

No abstractJACC Heart Fail. 2026 Jun 30:103225. doi: 10.1016/j.jchf.2026.103225. Online ahead of print.NO ABSTRACTPMID:42383961 | DOI:10.1016/j.jchf.2026.103225

Bilateral Modified Self-Expanding Valve Implantation in Branch Pulmonary Arteries

JACC Case Rep. 2026 Jul 1:108975. doi: 10.1016/j.jaccas.2026.108975. Online ahead of print.ABSTRACTBACKGROUND: Transcatheter pulmonary valve implantation (TPVI) in repaired tetralogy of Fallot is challenging due to right ventricular (RV) outflow tract complexity. Severe main pulmonary artery (PA) di

Ultra-Thin Sirolimus-Eluting Versus Everolimus-Eluting Stents in Diabetic Multivessel Coronary Artery Disease Patients: The TUXEDO-2 Trial

J Am Coll Cardiol. 2026 Jun 24:S0735-1097(26)06637-4. doi: 10.1016/j.jacc.2026.05.025. Online ahead of print.ABSTRACTBACKGROUND: Patients with diabetes frequently have multivessel disease and are at increased risk of adverse outcomes. The outcomes with a new-generation ultra-thin strut sirolimus-elu