CONCLUSIONS: PBMSC-Exos^(RD) enhances RD-mediated cardiac repair through miR-141-200-429 cluster-dependent activation of the Wnt/β-catenin pathway, offering a novel therapeutic strategy for MI-induced heart failure. Our findings unveil a novel therapeutic strategy, highlighting that RD maintains its
No abstractEuropace. 2025 Sep 1;27(9):euaf138. doi: 10.1093/europace/euaf138.NO ABSTRACTPMID:40910263 | DOI:10.1093/europace/euaf138
CONCLUSIONS: DWORF overexpression enhances SR Ca^(2+) dynamics, improves mitochondrial energetics, and attenuates pathological remodeling and heart failure progression in response to pressure overload. These findings support DWORF as a promising therapeutic target for heart failure.Circ Res. 2025 Se
CONCLUSIONS: This study established VO(2)T(12.5%) as a new measure that reflects cardiac performance during exercise and predicted heart failure event-free survival. Furthermore, VO(2)T(12.5%) improved proportional to improvements in left ventricular outflow tract gradient and cardiac biomarkers in
ACS Nano. 2025 Sep 5. doi: 10.1021/acsnano.5c07064. Online ahead of print.ABSTRACTMyocardial infarction (MI) is followed by irreversible damage to the myocardium, which eventually evolves into ventricular remodeling and heart failure. An imbalanced inflammatory response after MI can exacerbate myoca
Circ Heart Fail. 2025 Sep 5:e013074. doi: 10.1161/CIRCHEARTFAILURE.125.013074. Online ahead of print.ABSTRACTBACKGROUND: Although the effects of various combinations of treatments on mortality and morbidity outcomes in heart failure with reduced ejection fraction (HFrEF) have been evaluated, the imp
Front Cardiovasc Med. 2025 Aug 20;12:1643971. doi: 10.3389/fcvm.2025.1643971. eCollection 2025.ABSTRACTHeart failure (HF) management is advancing in the field of cardiology, driven by the increasing availability of progressive medications. Emerging pharmacological therapies in heart failure manageme
Front Public Health. 2025 Aug 20;13:1637112. doi: 10.3389/fpubh.2025.1637112. eCollection 2025.ABSTRACTINTRODUCTION: Post-acute sequelae of COVID-19 (PASC) encompass several clinical outcomes, from new-onset symptoms to both acute and chronic diagnoses, including pulmonary and extrapulmonary manifes
Front Pharmacol. 2025 Aug 20;16:1616162. doi: 10.3389/fphar.2025.1616162. eCollection 2025.ABSTRACTBACKGROUND: Epirubicin, a widely used anthracycline, effectively treats various cancers but poses a high risk of cardiotoxicity, leading to heart failure and myocardial dysfunction. This study conducts
bioRxiv [Preprint]. 2025 Aug 28:2025.08.22.671840. doi: 10.1101/2025.08.22.671840.ABSTRACTOBJECTIVE: To investigate the effects of carnosine on heart failure and to examine whether this is associated with reduced immunogenicity of oxidatively-generated aldehyde modified proteins.BACKGROUND: Heart fa
CONCLUSIONS: We found that the downregulation of Rps19bp1 , not loss of ATF4 function, underlying the cardiac phenotypes in Atf4 ^(cKO(e2/3/pA)) mice. The reduced expression of Rps19bp1 in Atf4 ^(cKO(e2/3/pA)) mice is likely due to the unintentional deletion of Atf4 polyA signal and subsequent trans
Front Med (Lausanne). 2025 Aug 20;12:1649217. doi: 10.3389/fmed.2025.1649217. eCollection 2025.ABSTRACTBleeding and thromboembolic events (BTE) increase the mortality of COVID-19 acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The current analysis
Eur Heart J Case Rep. 2025 Sep 3;9(9):ytaf377. doi: 10.1093/ehjcr/ytaf377. eCollection 2025 Sep.ABSTRACTBACKGROUND: Diagnosing the cause of undifferentiated left ventricular hypertrophy (LVH) in a patient with progressive heart failure symptoms can present a diagnostic challenge, with potential for
Eur Heart J Case Rep. 2025 Aug 16;9(9):ytaf402. doi: 10.1093/ehjcr/ytaf402. eCollection 2025 Sep.ABSTRACTBACKGROUND: Trauma-related acute myocardial infarction represents a complex and high-risk condition in the emergency department, necessitating a range of sophisticated treatment strategies. Failu
IJU Case Rep. 2025 Jun 24;8(5):466-469. doi: 10.1002/iju5.70068. eCollection 2025 Sep.ABSTRACTINTRODUCTION: Androgen receptor signaling inhibitors (ARSIs) improve survival in prostate cancer; however, it may increase cardiovascular risks, especially in elderly patients with heart disease.CASE PRESEN
IJU Case Rep. 2025 Aug 19;8(5):525-528. doi: 10.1002/iju5.70084. eCollection 2025 Sep.ABSTRACTINTRODUCTION: Renal artery stenosis (RAS) reduces renal blood flow and activates the renin-angiotensin-aldosterone (RAA) system, resulting in renovascular hypertension (RVH).CASE PRESENTATION: We report a c
Food Sci Nutr. 2025 Sep 3;13(9):e70841. doi: 10.1002/fsn3.70841. eCollection 2025 Sep.ABSTRACTMitochondrial dysfunction is increasingly recognized as a driver of sarcopenia pathogenesis, progression, and prognosis. Muscle mass is a fundamental and objective component of sarcopenia. In some studies,
Front Endocrinol (Lausanne). 2025 Aug 20;16:1663787. doi: 10.3389/fendo.2025.1663787. eCollection 2025.ABSTRACT[This corrects the article DOI: 10.3389/fendo.2025.1605746.].PMID:40909226 | PMC:PMC12406488 | DOI:10.3389/fendo.2025.1663787
Eur Heart J Open. 2025 Aug 20;5(5):oeaf109. doi: 10.1093/ehjopen/oeaf109. eCollection 2025 Sep.ABSTRACTAIMS: Deformation imaging remains underused for cardiovascular risk assessment. As tissue characterization has now been recognized as an additional assessment tool, we sought to investigate the sig
Cureus. 2025 Aug 4;17(8):e89322. doi: 10.7759/cureus.89322. eCollection 2025 Aug.ABSTRACTFulminant myocarditis is a rare but life-threatening complication of influenza A infection that can result in acute biventricular failure leading to cardiogenic shock. Here, we present the case of a young patien
Cardiol Young. 2025 Sep 5:1-8. doi: 10.1017/S1047951125109256. Online ahead of print.ABSTRACTIn the United States, about 1 in 100 children are born with a CHD, with complex cases requiring intensive, lifelong care. Despite medical severity, little data exist on economic burden, driving low impact sc
No abstractChin Med J (Engl). 2025 Sep 5. doi: 10.1097/CM9.0000000000003793. Online ahead of print.NO ABSTRACTPMID:40908909 | DOI:10.1097/CM9.0000000000003793
Qual Manag Health Care. 2025 Sep 5. doi: 10.1097/QMH.0000000000000535. Online ahead of print.ABSTRACTBACKGROUND: Heart failure (HF) readmission rates at our institution were often higher than the expected levels for our institution type. Social work post-discharge telephone calls were identified as
J Clin Ultrasound. 2025 Sep 5. doi: 10.1002/jcu.70064. Online ahead of print.ABSTRACTDanon disease is an X-chromosome dominant disorder caused by variants in lysosomal-associated membrane protein-2 (LAMP-2). Patients often present with cardiac lesions as their initial symptom, including hypertrophic
