The influence of recipient's pre-existing diabetes mellitus on outcomes of living donor kidney transplant

Pak J Med Sci. 2026 Sep;42(9):2199-2205. doi: 10.12669/pjms.42.9.13651.ABSTRACTOBJECTIVE: To determine the influence of recipients' pre-existing diabetes mellitus on the outcomes of living donor kidney transplantation.METHODOLOGY: This prospective observational cohort study included 202 patients who

Digital Twins and Offline Reinforcement Learning for Mechanical Circulatory Support Decisions: What the Current Evidence Can and Cannot Support

Cureus. 2026 Sep 30;18(9):e117234. doi: 10.7759/cureus.117234. eCollection 2026 Sep.ABSTRACTMechanical circulatory support (MCS) is not a single intervention but a sequence of decisions: whether to initiate support, which device to use, how to titrate it while other therapies change, when to test fo

Relationship Between Obesity, Insulin Resistance, and Gastrointestinal Disorders Among Adult Patients With Established Cardiovascular Disease

Cureus. 2026 Aug 31;18(8):e115506. doi: 10.7759/cureus.115506. eCollection 2026 Aug.ABSTRACTBackground Obesity and insulin resistance (IR) are major cardiometabolic abnormalities that frequently coexist with cardiovascular disease (CVD) and may contribute to gastrointestinal (GI) morbidity. Objectiv

Integrative multi-omics analysis unveils the regulatory landscape of diabetic cardiomyopathy: from chromatin accessibility to transcript isoforms and epitranscriptome

Front Endocrinol (Lausanne). 2026 Sep 16;17:1928778. doi: 10.3389/fendo.2026.1928778. eCollection 2026.ABSTRACTDiabetic cardiomyopathy (DCM) is a major contributor to heart failure in diabetic patients, characterized by profound metabolic remodeling and diastolic dysfunction. However, the multi-laye

Effect of a Self-Regulation Skills Training Program on Cognitive Flexibility in Patients With Heart Failure: A Randomized Controlled Trial

Health Sci Rep. 2026 Sep 29;9(10):e73306. doi: 10.1002/hsr2.73306. eCollection 2026 Oct.ABSTRACTBACKGROUND: Psychological well-being is a critical component of disease management and recovery in patients with cardiovascular disorders. Cognitive flexibility, as a key psychological determinant, signif

Exercise-based Rehabilitation in Cardio-renal-pulmonary Multimorbidity: Shared Pathophysiology, Functional Phenotypes, and Clinical Implications

Phys Ther Res. 2026;29(2):87-96. doi: 10.1298/ptr.R0044. Epub 2026 Jul 7.ABSTRACTHeart failure (HF), chronic kidney disease (CKD), and chronic obstructive pulmonary disease (COPD) frequently coexist and collectively constitute a high-risk multimorbid state characterized by shared pathophysiology, co

A comparative analysis of cardiac bridging Integrator 1 (cBIN1) levels in patients with heart failure and healthy controls: A prospective case-control study

Pak J Med Sci. 2026 Sep;42(9):2588-2594. doi: 10.12669/pjms.42.9.16094.ABSTRACTOBJECTIVES: To compare cardiac bridging integrator 1 (cBIN1) levels between healthy individuals and patients with heart failure (HF), and to assess changes in cBIN1 levels following therapeutic intervention to evaluate it

Predictive value of baseline, cumulative exposure and annual mean changes in TyG-related indices for cardiovascular events in older rural adults with cardiovascular-kidney-metabolic syndrome stages 0-3: a cohort study

Front Endocrinol (Lausanne). 2026 Sep 30;17:1952253. doi: 10.3389/fendo.2026.1952253. eCollection 2026.ABSTRACTBACKGROUND: The triglyceride-glucose (TyG) index and its derivatives are cost-effective markers of insulin resistance and cardiovascular risk. However, the comparative predictive value of b

Association between the alkaline phosphatase-to-albumin ratio and recorded early all-cause mortality within 90 days of admission in patients with heart failure: a retrospective cohort study in a Chinese population

Front Cardiovasc Med. 2026 Sep 16;13:1936612. doi: 10.3389/fcvm.2026.1936612. eCollection 2026.ABSTRACTBACKGROUND: APAR combines alkaline phosphatase and albumin, two routine laboratory measurements. We examined its association with recorded early all-cause mortality within 90 days of admission in h

Conduction system pacing as a rescue strategy for unsuccessful cardiac resynchronisation therapy implantation

Front Physiol. 2026 Sep 16;17:1929170. doi: 10.3389/fphys.2026.1929170. eCollection 2026.ABSTRACTBACKGROUND: Failure to achieve effective cardiac resynchronisation therapy (CRT) remains a clinically significant challenge, often driven by anatomical constraints or suboptimal left ventricular lead per

Study protocol for a factorial randomized trial of behavioral interventions to increase health care proxy documentation among older and seriously ill adults

medRxiv [Preprint]. 2026 Sep 7:2026.09.02.26362062. doi: 10.64898/2026.09.02.26362062.ABSTRACTINTRODUCTION: Health care proxies serve as surrogate decision-makers for patients with limited decisional capacity, yet only one in three U.S. adults have designated one. This trial will evaluate low-cost,

Physiological Aging and Cardiovascular Disease Distinctly Remodel the Human Cardiac Lymphatic Endothelium

bioRxiv [Preprint]. 2026 Sep 25:2026.09.22.750171. doi: 10.64898/2026.09.22.750171.ABSTRACTAIMS: Cardiac lymphatic endothelial cells (LECs) regulate tissue homeostasis, immune trafficking, and remodeling, but how human cardiac LEC heterogeneity changes with physiological aging and cardiovascular dis

CardioChrom Reconstructs the Human Cardiac Virtual Epigenome from Single-Nucleus Transcriptomes

bioRxiv [Preprint]. 2026 Sep 24:2026.09.18.752723. doi: 10.64898/2026.09.18.752723.ABSTRACTBACKGROUND: Matched epigenomic profiling remains scarce in human heart failure, limiting regulatory interpretation of single-nucleus ribonucleic acid (RNA) sequencing data. We developed CardioChrom, a cardiac-

Empagliflozin Improves Angina and Endothelial Dysfunction Indices in Angina and No Obstructive Coronary Arteries (ANOCA)

Arterioscler Thromb Vasc Biol. 2026 Oct 1. doi: 10.1161/ATVBAHA.126.324735. Online ahead of print.ABSTRACTBACKGROUND: Treatments targeting endothelial dysfunction in patients with angina and no obstructive coronary arteries (ANOCA) and coronary microvascular and vasomotor dysfunction (CMVD) are lack

PET Imaging in Pulmonary Hypertension

Arterioscler Thromb Vasc Biol. 2026 Oct 1. doi: 10.1161/ATVBAHA.126.324761. Online ahead of print.ABSTRACTPulmonary hypertension comprises a heterogeneous group of diseases characterized by elevated pulmonary arterial pressures and progressive right ventricular (RV) remodeling, with RV failure as th

What's New in Heart Failure? September 2026

No abstractEur J Heart Fail. 2026 Oct 1:xuag302. doi: 10.1093/ejhf/xuag302. Online ahead of print.NO ABSTRACTPMID:42817850 | DOI:10.1093/ejhf/xuag302

Pharmacological treatment strategies to prevent heart failure across the cardiovascular-kidney-metabolic spectrum: an EJHF Expert Consensus Statement

Eur J Heart Fail. 2026 Oct 1:xuag301. doi: 10.1093/ejhf/xuag301. Online ahead of print.ABSTRACTHeart failure (HF) remains a major cause of morbidity, mortality, and increased healthcare costs worldwide, and is recognized as the result of progressive cardiovascular-kidney-metabolic (CKM) syndrome. Ob

Cell Therapy for Heart Failure and Myocardial Infarction: Evidence Evolution and Translational Challenges Over Two Decades

Curr Stem Cell Res Ther. 2026 Sep 29. doi: 10.2174/011574888X500658260921112146. Online ahead of print.ABSTRACTINTRODUCTION: Cell-based myocardial repair has progressed from direct cell replacement toward paracrine, engineered tissue, and cell-free strategies, but the relationship between preclinica

Endothelial Dysfunction and Inflammatory Pathways in Heart Failure - Role of suPAR and sVCAM-1 as Novel Biomarkers

Curr Cardiol Rev. 2026 Sep 30. doi: 10.2174/011573403X522286260923132142. Online ahead of print.ABSTRACTINTRODUCTION: Heart failure (HF) is a multifactorial clinical syndrome characterised by myocardial remodelling, endothelial dysfunction, and chronic inflammation. Emerging evidence highlights the

Slow calcium removal contributes to impaired lusitropic response to β-adrenergic stimulation in HFpEF mice

J Physiol. 2026 Sep 30. doi: 10.1113/JP291587. Online ahead of print.ABSTRACTHeart failure with preserved ejection fraction (HFpEF) accounts for over half of heart failure cases, yet its underlying mechanisms remain incompletely understood and effective therapies are lacking. Diastolic dysfunction,

Validation of the Self-Care Self-Efficacy Scale (SCSE) in a Colombian Population

Hisp Health Care Int. 2026 Sep 30:15404153261487650. doi: 10.1177/15404153261487650. Online ahead of print.ABSTRACTIntroductionSelf-efficacy is essential in heart failure (HF) management, influencing treatment adherence, symptom recognition, and self-care decisions. The Self-Care Self-Efficacy Scale

Large Pulmonary Valve Vegetation Causing Right Ventricular Outflow Tract Obstruction in an Infant: Successful Complete Excision and Valve-Preserving Surgical Management

World J Pediatr Congenit Heart Surg. 2026 Sep 30:21501351261472488. doi: 10.1177/21501351261472488. Online ahead of print.ABSTRACTIsolated pulmonary valve infective endocarditis is exceedingly rare in infancy. We report an 8-month-old male infant presenting with feeding diaphoresis, failure to thriv

Body Roundness Index Trajectories and Incident Left Ventricular Hypertrophy: Results of a Community-Based Study in Korea

Echocardiography. 2026 Oct;43(10):e70644. doi: 10.1111/echo.70644.ABSTRACTBACKGROUND: Left ventricular hypertrophy (LVH) constitutes Stage B heart failure and marks elevated risk for atrial fibrillation, stroke, and death. Unlike body mass index, body roundness index (BRI), derived from waist circum

Comparative Prognostic Performance of BMI- and Height-Indexed Muscle Mass in Older Patients With Heart Failure: Insights From FRAGILE-HF

J Am Geriatr Soc. 2026 Sep 30. doi: 10.1111/jgs.70766. Online ahead of print.ABSTRACTAmong older patients hospitalized for heart failure, height-indexed appendicular skeletal muscle mass, but not BMI-indexed appendicular skeletal muscle mass, was associated with higher 2-year mortality. Height-index