Strengthening the case for earlier LDL cholesterol lowering
No abstractEur Heart J. 2025 Sep 5:ehaf589. doi: 10.1093/eurheartj/ehaf589. Online ahead of print.NO ABSTRACTPMID:40910356 | DOI:10.1093/eurheartj/ehaf589
Alteration of cardiac energetics and mitochondrial function in doxorubicin‑induced cardiotoxicity: Molecular mechanism and prospective implications (Review)
Int J Mol Med. 2025 Nov;56(5):183. doi: 10.3892/ijmm.2025.5624. Epub 2025 Sep 5.ABSTRACTDoxorubicin (DOX)‑induced cardiotoxicity (DIC) remains a critical challenge in cancer therapy, significantly limiting its use in clinical practice. The underlying mechanisms involve disruptions in cardiac metabol
DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function
CONCLUSIONS: DWORF overexpression enhances SR Ca^(2+) dynamics, improves mitochondrial energetics, and attenuates pathological remodeling and heart failure progression in response to pressure overload. These findings support DWORF as a promising therapeutic target for heart failure.Circ Res. 2025 Se
Indobufen Versus Aspirin Plus Clopidogrel in Patients After Coronary Stenting in Patients With Diabetes: A Post Hoc Analysis of the OPTION Trial
J Diabetes. 2025 Sep;17(9):e70152. doi: 10.1111/1753-0407.70152.ABSTRACTBACKGROUND: Despite increased risk of ischemic events in diabetes, the optimal anti-thrombotic strategy for secondary prevention has not been defined. We aimed to assess the efficacy and safety of optimal antiplatelet agents suc
Divergence in Estimated Risks and Actual Rates of Atherosclerotic Cardiovascular Events and their Management in a Longitudinal Cohort of Patients with Dermatomyositis with Skin Involvement
JID Innov. 2025 Jul 7;5(6):100399. doi: 10.1016/j.xjidi.2025.100399. eCollection 2025 Nov.ABSTRACTPatients with dermatomyositis (DM), an autoimmune disorder affecting the skin, muscle, and lung, have been reported to be at a heightened risk of clinical events, chiefly heart attacks and strokes, from
Association of sedentary behavior with atrial fibrillation-related biomarkers in a population with overweight or obesity
medRxiv [Preprint]. 2025 Aug 28:2025.08.25.25334401. doi: 10.1101/2025.08.25.25334401.ABSTRACTBACKGROUND: Blood biomarkers can characterize the atrial substrate, helping to elucidate mechanisms of atrial fibrillation (AF) development. Understanding whether sedentary behavior affects AF-related bioma
Impact of bleeding and thrombosis on outcome of 945 COVID-19 VV-ECMO cases from a German registry
Front Med (Lausanne). 2025 Aug 20;12:1649217. doi: 10.3389/fmed.2025.1649217. eCollection 2025.ABSTRACTBleeding and thromboembolic events (BTE) increase the mortality of COVID-19 acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The current analysis
Genetic diagnosis and clinical characteristics analysis of cardiospondylocarpofacial syndrome in a Chinese family
Front Pediatr. 2025 Aug 20;13:1651803. doi: 10.3389/fped.2025.1651803. eCollection 2025.ABSTRACTCardiospondylocarpofacial syndrome (CSCFS) is an extremely rare autosomal dominant disorder resulting from variant in the MAP3K7 gene, which encodes the transforming growth factor-β-activated kinase 1 (TA
The challenge of secondary cardiovascular prevention in very high Lipoprotein (a) level: a case report
Eur Heart J Case Rep. 2025 Aug 9;9(9):ytaf389. doi: 10.1093/ehjcr/ytaf389. eCollection 2025 Sep.ABSTRACTBACKGROUND: While advances in technology and procedural techniques have significantly improved outcomes post-PCI, two pharmacological strategies have gained particular attention for their effectiv
The PARCS Pilot Study Randomized Controlled Trial: Feasibility and Acceptability of a Park-Based Exercise Program Led by Peer Specialists for Peers with Serious Mental Illness
J Healthy Eat Act Living. 2025 Jun 1;5(2):146-160. eCollection 2025.ABSTRACTAdults with serious mental illness (SMI) die decades early, mostly from heart disease. Few park-based exercise interventions have been tested, none focused on SMI. The study (NCT05293587) tested a 6-week exercise interventio
Dietary Phytochemicals in Cardiovascular Disease Prevention and Management: A Comprehensive Review
Food Sci Nutr. 2025 Sep 3;13(9):e70872. doi: 10.1002/fsn3.70872. eCollection 2025 Sep.ABSTRACTCardiovascular disease (CVD) is the leading cause of death worldwide and a major public health issue. According to recent World Health Organization (WHO) estimates, CVD causes approximately 17.9 million dea
Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expression
Front Bioeng Biotechnol. 2025 Aug 20;13:1636883. doi: 10.3389/fbioe.2025.1636883. eCollection 2025.ABSTRACTBACKGROUND: Isowighteone, an isoflavonoid compound derived from Ficus hispida L.f. (F. hispida, Moraceae), has demonstrated significant anti-inflammatory properties in prior studies. However, i
Cardiovascular Health in Women-Across the Lifespan
Clin Endocrinol (Oxf). 2025 Sep 5. doi: 10.1111/cen.70027. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains under
US eligibility and preventable cardiovascular disease events from semaglutide in type 2 diabetes
Diab Vasc Dis Res. 2025 Sep-Oct;22(5):14791641251376551. doi: 10.1177/14791641251376551. Epub 2025 Sep 4.ABSTRACTBackgroundThe SUSTAIN-6 trial showed the cardiovascular disease (CVD) benefits of semaglutide among patients with type 2 diabetes mellitus (T2DM). We estimated the US population eligibili
Cardiac Dual-Targeting Nanocatalysts for Heart Failure Therapy by Breaking the ROS-Inflammation Positive Feedback
Adv Healthc Mater. 2025 Sep 4:e03020. doi: 10.1002/adhm.202503020. Online ahead of print.ABSTRACTHeart failure (HF) is a global public health challenge closely associated with oxidative stress and immune dysregulation. However, current therapeutic strategies for HF generally lack specific targeting
Isoquercitrin Promotes Angiogenesis Through the Genomic Signaling Pathway of the Estrogen Receptor-Alpha
Phytother Res. 2025 Sep 4. doi: 10.1002/ptr.70082. Online ahead of print.ABSTRACTPostmenopausal women's estrogen decline is a key factor for cardiovascular disease (CVD). Phytoestrogen may prevent CVD by protecting vascular endothelium and inhibiting vascular smooth muscle proliferation via receptor
Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage-Derived N2ICD-Enriched Extracellular Vesicles
Adv Sci (Weinh). 2025 Sep 4:e04607. doi: 10.1002/advs.202504607. Online ahead of print.ABSTRACTPersistent overactivation of the renal sympathetic nervous system drives kidney inflammation and fibrosis. Macrophages contribute to fibrogenesis by secreting various pro-fibrogenic mediators. However, whe
Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study
Am J Hypertens. 2025 Aug 16:hpaf154. doi: 10.1093/ajh/hpaf154. Online ahead of print.ABSTRACTBACKGROUND: The relationship between childhood and adulthood obesity and the risk of gestational diabetes mellitus (GDM) remains unclear. To clarify the independent and joint effects of childhood and adultho
Accelerated biological ageing and cardiovascular disease trajectories: a multistate analysis
Heart. 2025 Sep 4:heartjnl-2025-325881. doi: 10.1136/heartjnl-2025-325881. Online ahead of print.ABSTRACTBACKGROUND: Accelerated biological ageing has been linked to elevated risks of hypertension (HTN) and cardiovascular diseases (CVDs), yet its role in shaping the dynamic progression from health t
What Can Atherosclerosis Imaging Teach Us About Healthy Vascular Aging?
No abstractJACC Cardiovasc Imaging. 2025 Sep;18(9):994-996. doi: 10.1016/j.jcmg.2025.07.014.NO ABSTRACTPMID:40908077 | DOI:10.1016/j.jcmg.2025.07.014
Ubiquitin-specific protease 7 promotes the growth and oncogenic potential of acute myeloid leukemia cells through the deubiquitination and upregulation of LRRK2
J Biol Chem. 2025 Sep 2:110675. doi: 10.1016/j.jbc.2025.110675. Online ahead of print.ABSTRACTLeucine-rich repeat kinase 2 (LRRK2), a large protein with kinase and GTPase activities, regulates various cellular pathways, including autophagy, endocytosis, and mitochondrial dynamics. LRRK2, extensively
The Clinical Impact of Intravascular Imaging-Guided Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients with High Thrombus Burden
Am J Cardiol. 2025 Sep 2:S0002-9149(25)00537-5. doi: 10.1016/j.amjcard.2025.08.064. Online ahead of print.ABSTRACTDespite the established clinical efficacy following intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) than angiography-guided PCI, evidence regarding prognostic
From obesity to comorbidities: A comprehensive care approach for improved health by the Spanish Society of Internal Medicine
Rev Clin Esp (Barc). 2025 Sep 2:502352. doi: 10.1016/j.rceng.2025.502352. Online ahead of print.ABSTRACTObesity is currently recognized as a chronic, progressive, and relapsing disease, and constitutes a major global public health challenge. This document, promoted by the Spanish Society of Internal
Comparative effectiveness of sodium-glucose cotransporter 2 inhibitors along with colchicine versus colchicine alone among coronary artery disease and type 2 diabetes patients
Prog Cardiovasc Dis. 2025 Sep 2:S0033-0620(25)00132-X. doi: 10.1016/j.pcad.2025.08.010. Online ahead of print.ABSTRACTBACKGROUND: Colchicine, an anti-inflammatory agent, has been demonstrated to reduce adverse cardiovascular events in coronary artery disease (CAD) patients. Sodium-Glucose Cotranspor