Global Burden of Heart Failure Attributable to Atrial Fibrillation and Flutter, insights from GBD 2021

ESC Heart Fail. 2026 Mar 30:xvag094. doi: 10.1093/eschf/xvag094. Online ahead of print.ABSTRACTAIMS: To systematically quantify the global, regional, and national burden of heart failure (HF) attributable to atrial fibrillation/flutter (AF/AFL) from 1990 to 2021, and project trends to 2040.METHODS A

Effectiveness of non-pharmacological and pharmacological interventions in preventing delirium in older adults: a systematic review and meta-analysis of randomised controlled trials

Age Ageing. 2026 Mar 16;55(3):afag068. doi: 10.1093/ageing/afag068.ABSTRACTBACKGROUND: Delirium is a serious neuropsychiatric condition common among older adults, associated with prolonged hospital stays, increased morbidity and mortality. Although guidelines emphasise prevention, identifying most e

Cardiopulmonary exercise testing in male adolescent patients with thalassemia major after blood transfusion

Physiol Int. 2026 Mar 30:2060.2026.00807. doi: 10.1556/2060.2026.00807. Online ahead of print.ABSTRACTBACKGROUND: Thalassemia major (TM) is characterized by anemia, and a synthesis defect occurs in both beta globin genes on the short arm of chromosome 11. Thalassemia patients suffer fatigue, and dec

Lead-Attributable Cardiovascular Disease Burden: Global Burden of Disease Study 2023

JAMA. 2026 Mar 30. doi: 10.1001/jama.2026.2197. Online ahead of print.ABSTRACTIMPORTANCE: Despite declines, lead exposure remains a major risk factor for cardiovascular disease (CVD) mortality. Quantifying the direct effects of cumulative bone lead exposure on CVD is essential to guide prevention an

Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial

Geroscience. 2026 Mar 30. doi: 10.1007/s11357-026-02197-9. Online ahead of print.ABSTRACTDespite widespread use in the USA, little is known about the impact of multivitamin-multimineral (MVM) supplementation on metabolomic profiles and how this may translate to biological aging and long-term risk of

Heparin protocols in cardiovascular surgery for antiphospholipid syndrome: a clinical case report

Egypt Heart J. 2026 Mar 30;78(1):20. doi: 10.1186/s43044-026-00731-w.ABSTRACTBACKGROUND: Antiphospholipid syndrome (APS) is a prothrombotic disorder that presents significant challenges during cardiovascular surgery due to its high risk of both thrombotic and hemorrhagic complications. Perioperative

Impact of atrial fibrillation catheter ablation on primary prevention ICD eligibility in heart failure with reduced ejection fraction: a systematic review and meta-analysis

No abstractJ Interv Card Electrophysiol. 2026 Mar 30. doi: 10.1007/s10840-026-02302-0. Online ahead of print.NO ABSTRACTPMID:41910893 | DOI:10.1007/s10840-026-02302-0

Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study

Clin Res Cardiol. 2026 Mar 30. doi: 10.1007/s00392-026-02902-w. Online ahead of print.ABSTRACTBACKGROUND: Noise pollution is increasingly recognized as a cardiovascular hazard, yet its contribution to early-onset myocardial infarction (EOMI) has not yet been investigated before.METHODS: This study i

Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations

Infect Dis Ther. 2026 Mar 30. doi: 10.1007/s40121-026-01313-8. Online ahead of print.ABSTRACTINTRODUCTION: Respiratory syncytial virus (RSV) poses a significant health risk to older adults, particularly those with chronic comorbidities, in the Gulf Cooperation Council (GCC) countries. Despite its hi

Automated hemodynamic management system for the prevention of hypotension and cardiac output reduction during general anesthesia: preclinical experimental validation

J Anesth. 2026 Mar 30. doi: 10.1007/s00540-026-03720-0. Online ahead of print.ABSTRACTPURPOSE: Intraoperative hypotension and cardiac output (CO) reduction adversely affect outcomes and require cause-specific treatment against vasodilation and/or hemorrhage. However, tight hemodynamic management inc

Stent Thrombosis: A Narrative Review From Pathophysiology to Therapy

Clin Cardiol. 2026 Apr;49(4):e70286. doi: 10.1002/clc.70286.ABSTRACTBACKGROUND: Stent thrombosis (ST) remains a rare but potentially life-threatening complication of percutaneous coronary intervention (PCI), associated with high rates of myocardial infarction and mortality. Despite advances in stent

Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation

N Engl J Med. 2026 Mar 28. doi: 10.1056/NEJMoa2517213. Online ahead of print.ABSTRACTBACKGROUND: For patients with atrial fibrillation, the use of oral anticoagulant therapy to prevent stroke is limited by the risk of bleeding. Left atrial appendage closure is considered for patients who are unsuita

Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease

N Engl J Med. 2026 Mar 28. doi: 10.1056/NEJMoa2600283. Online ahead of print.ABSTRACTBACKGROUND: Despite guideline recommendations, evidence from randomized trials evaluating the appropriate low-density lipoprotein (LDL) cholesterol target for secondary prevention in patients with atherosclerotic ca

The urgency of addressing the physical inactivity crisis in the Eastern Mediterranean Region

East Mediterr Health J. 2026 Mar 5;32(3):127-128. doi: 10.26719/2026.32.3.127.ABSTRACTNoncommunicable diseases (NCDs) remain the foremost cause of premature mortality across the Eastern Mediterranean Region (EMR). Cardiovascular disease, cancer, diabetes, and chronic respiratory conditions together

Case Report: Transient perivascular inflammation of the carotid artery syndrome: a rare etiology of self-limiting carotidynia

Front Immunol. 2026 Mar 13;17:1698493. doi: 10.3389/fimmu.2026.1698493. eCollection 2026.ABSTRACTOBJECTIVES: Transient perivascular inflammation of the carotid artery (TIPIC) syndrome is a recently recognized clinicoradiological entity that has not yet been formally incorporated into established dis

Molecular determinants of STEC-HUS: from complement activation to microvascular thrombosis

Front Immunol. 2026 Mar 13;17:1749811. doi: 10.3389/fimmu.2026.1749811. eCollection 2026.ABSTRACTShiga-like toxin-producing E. coli-induced hemolytic uremic syndrome (STEC-HUS) is a rare but severe disease characterized by microangiopathic hemolysis, thrombocytopenia, and renal failure. No specific

Evaluation of electrocardiographic alterations before and after bariatric surgery

Glob Cardiol Sci Pract. 2025 May 15;2025(2):e202522. doi: 10.21542/gcsp.2025.22. eCollection 2025 May 15.ABSTRACTBackground: Obesity is a key risk factor for cardiac arrhythmia and sudden cardiac death. Additionally, morbid obesity is associated with an acquired elongation of the corrected QT interv

VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia

Blood Vessel Thromb Hemost. 2026 Mar 3;3(2):100146. doi: 10.1016/j.bvth.2026.100146. eCollection 2026 May.ABSTRACTHeparin-induced thrombocytopenia (HIT) is an immune prothrombotic disorder characterized by the binding of platelet-activating immunoglobulin G antibodies to platelet factor 4/heparin. I

Heme cascade-triggered nanovesicles for myocardial ischemic core delivery

Bioact Mater. 2026 Mar 21;62:655-668. doi: 10.1016/j.bioactmat.2026.03.027. eCollection 2026 Aug.ABSTRACTMyocardial ischemia-reperfusion injury (MIRI) remains a significant therapeutic challenge due to insufficient targeted drug delivery. Recognizing heme as a key endogenous signal that has yet to b

Multiethnic community cardio-metabolic risk factor screening in Northeast Florida: The VIDASANA Project

Am Heart J Plus. 2026 Mar 12;64:100755. doi: 10.1016/j.ahjo.2026.100755. eCollection 2026 Apr.ABSTRACTBACKGROUND: Cardiometabolic risk disproportionately affects racially and ethnically diverse United States populations. Few community-based studies have examined the intersection of metabolic syndrom

Acute Cardiac Tamponade During Multiple Electrical Pre-Mappings for Atrial Leadless Pacemaker Implantation

J Arrhythm. 2025 Oct 7;41(5):e70202. doi: 10.1002/joa3.70202. eCollection 2025 Oct.ABSTRACTAlthough cardiac tamponade during atrial leadless pacemaker implantation (ALPI) is rare, we encountered such an incident in a female patient with a lower body mass index during multiple pre-mapping attempts. D

Incomplete Kawasaki Disease Complicated by Shock: A Diagnostic Challenge in a Child

Cureus. 2026 Feb 25;18(2):e104268. doi: 10.7759/cureus.104268. eCollection 2026 Feb.ABSTRACTKawasaki disease (KD) is an acute vasculitis of medium-sized vessels that primarily affects children. It can present with incomplete or atypical features, leading to diagnostic delay and increased risk of car

Incidence and clinical manifestations of sudden death in young adults: a two-decade, nationwide, retrospective, cross-sectional study

Resusc Plus. 2026 Mar 9;29:101285. doi: 10.1016/j.resplu.2026.101285. eCollection 2026 May.ABSTRACTAIM: Sudden death in healthy young adults is a rare but devastating event, and its causes and clinical features are not well understood. We describe the clinical manifestations and causes of sudden dea

Dynamic versus Static Metabolic Models for Predicting ECG-Defined Cardiovascular Risk in Elderly MAFLD: A Three-Year Cohort Study

Clin Interv Aging. 2026 Feb 5;21:567520. doi: 10.2147/CIA.S567520. eCollection 2026.ABSTRACTPURPOSE: Given the high and rising prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) among the aging population and its established link to cardiovascular risk, this study aimed to ev