hERG1 channels and potential therapeutics for long QT syndrome

J Physiol. 2026 Jul 1. doi: 10.1113/JP291452. Online ahead of print.ABSTRACTThe human ether-à-go-go-related gene type 1 (hERG1) channel is a voltage-gated potassium channel encoded by the KCNH2 gene. hERG1 channels are essential to the repolarization of cardiac action potentials, and reduced functio

STEMIN- and YAP5SA-induced exosomes prevent cardiomyocyte apoptosis

iScience. 2026 Jun 22;29(7):116277. doi: 10.1016/j.isci.2026.116277. eCollection 2026 Jul 17.ABSTRACTCardiac regeneration strategies increasingly leverage transient reprogramming to restore function in damaged myocardium. Here, we show that delivery of modRNA encoding STEMIN, a modified serum respon

2021 Clinical Practice Guidelines on Periodic Health Examination

Acta Med Philipp. 2026 May 30;60(10):7-27. doi: 10.47895/amp.v60i10.12061. eCollection 2026.ABSTRACTBACKGROUND AND OBJECTIVE: The first Philippine Guidelines on Periodic Health Examination (PHEX) provided evidence-based recommendations for prevention strategies in the Philippines, published in 2004.

DOCK8 in immune cells: roles and mechanisms

Front Immunol. 2026 Jun 16;17:1854442. doi: 10.3389/fimmu.2026.1854442. eCollection 2026.ABSTRACTDOCK8 (dedicator of cytokinesis 8) is a prominent member of the DOCK-C subfamily and functions as an atypical guanine nucleotide exchange factor (GEF). It primarily activates Rho family small GTPases-mos