Brain Inform. 2026 May 16. doi: 10.1186/s40708-026-00301-5. Online ahead of print.
ABSTRACT
Advances in brain imaging have generated unprecedented volumes of high-dimensional data, yet extracting meaningful information from complex, noisy, and incomplete brain imaging data remains a significant challenge. Diffusion models (DMs) have introduced a paradigm shift in this field, surpassing traditional generative approaches. This review systematically examines the theoretical foundations of diffusion models, and their practical applications in eight brain imaging computing tasks: registration, super-resolution, cross-modal reconstruction and synthesis, segmentation, classification, brain network analysis, brain-computer interface (BCI) signals augmentation, and BCI decoding. Additionally, we emphasize obstacles that hinder deployment in practice, including computational scalability and sampling inefficiency, limited generalization under domain shift sensitivity, as well as multimodal integration and alignment constraints, while outlining potential future directions that emphasize the convergence of diffusion models with large-scale foundation models, which hold the potential to advance scalable, reliable, and clinically embedded brain imaging solutions. Throughout this review, we aim to establish a roadmap of progress and translational hurdles to guide emerging research and accelerate collaboration spanning DMs, clinical brain imaging, and engineering disciplines.
PMID:42143201 | DOI:10.1186/s40708-026-00301-5