Ther Apher Dial. 2026 Jul 1. doi: 10.1002/1744-9987.70180. Online ahead of print.
ABSTRACT
BACKGROUND: Arterial stiffness is an important cardiovascular risk marker in hemodialysis patients. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and triglyceride-glucose (TyG) index are laboratory-based markers related to inflammation, lipid metabolism, and insulin resistance. This study evaluated their association with arterial stiffness.
METHODS: This cross-sectional study included 120 adults receiving maintenance hemodialysis. Arterial stiffness was assessed by pulse wave velocity (PWV), and patients were classified as PWV > 10 or ≤ 10 m/s. Correlation and multivariable linear regression analyses were performed to identify factors associated with PWV.
RESULTS: A total of 29 patients had PWV > 10 m/s. PWV was associated with both the TyG index and MHR in unadjusted analyses. Patients with arterial stiffness were older and had higher systolic blood pressure. In multivariable analysis, only age and systolic blood pressure remained independently associated with PWV.
CONCLUSIONS: Age and systolic blood pressure were the main determinants of arterial stiffness. Although MHR and the TyG index correlated with PWV, their independent predictive value appeared limited.
PMID:42383580 | DOI:10.1002/1744-9987.70180